caa a22 4500 445376562 CHVBK 20180317143004.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00702-010-0562-9 doi (NATIONALLICENCE)springer-10.1007/s00702-010-0562-9 Transcriptional regulation and multiple functions of MAO genes [Elektronische Daten] [Jean Shih, Jason Wu, Kevin Chen] Monoamine oxidase (MAO) A and MAO B are a crucial pair of isoenzymes, which oxidatively deaminate monoamine neurotransmitters and dietary amines with a production of hydrogen peroxide. These two isoenzymes have different but overlapping substrate and inhibitor specificities. MAO A and MAO B share 70% amino acid sequence identity and show different temporal and spatial expressions in both humans and mice. Abnormal MAO A or MAO B activity has been implicated in numerous neurological and psychiatric disorders. A better understanding of the transcriptional regulation of MAO A and MAO B genes may help explain the differential tissue-specific expression of these two isoenzymes and provide insights into the molecular basis of the disorders associated with MAO dysfunction. This review discusses the recent progress in the transcriptional regulation and multiple functions of MAO A and MAO B genes. Springer-Verlag, 2011 Monoamine oxidase nationallicence Promoter nationallicence Transcriptional regulation nationallicence Hormone nationallicence Sp1 nationallicence Shih Jean Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Room 518, 90089, Los Angeles, CA, USA aut Wu Jason Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Room 518, 90089, Los Angeles, CA, USA aut Chen Kevin Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Room 518, 90089, Los Angeles, CA, USA aut Journal of Neural Transmission Springer Vienna 118/7(2011-07-01), 979-986 0300-9564 118:7<979 2011 118 702 https://doi.org/10.1007/s00702-010-0562-9 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-010-0562-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shih Jean Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Room 518, 90089, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Wu Jason Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Room 518, 90089, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Chen Kevin Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Room 518, 90089, Los Angeles, CA, USA aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/7(2011-07-01), 979-986 0300-9564 118:7<979 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer