caa a22 4500 44537666X CHVBK 20180317143004.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00702-010-0434-3 doi (NATIONALLICENCE)springer-10.1007/s00702-010-0434-3 Increased iron levels correlate with the selective nigral dopaminergic neuron degeneration in Parkinson's disease [Elektronische Daten] [Zhanyun Lv, Hong Jiang, Huamin Xu, Ning Song, Junxia Xie] The staging of Lewy-related pathology in sporadic Parkinson's disease (PD) reveals that many brain nuclei are affected in PD during different stages, except the ventral tegmental area (VTA), which is close related to the substantia nigra (SN) and enriched in dopamine (DA) neurons. Why DA neurons are selectively degenerated in the SN of PD is far from known. In the present study, we observed that the number of tyrosine hydroxylase immunoreactive neurons decreased and iron-staining positive cells increased in the SN, but not in the VTA, in the chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated PD mice. Increased expression of divalent metal transporter 1 and decreased expression of ferroportin 1 might associate with this increased nigral iron levels. Lipofuscin granular aggregations and upregulation of alpha-synuclein (α-synuclein) were also observed only in the SN. These results suggest that increased iron levels associate with the selective degeneration of DA neurons in the SN. The intracellular regulation mechanisms for the iron transporters may be different in the SN and VTA under the same conditions. Moreover, the lipofuscin granular aggregations and upregulation of α-synuclein were also involved in the selective degeneration of dopaminergic neurons in the SN. Springer-Verlag, 2010 Divalent metal transporter 1 nationallicence Ferroportin 1 nationallicence Iron nationallicence Α-synuclein nationallicence Parkinson's disease nationallicence Lv Zhanyun Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Medical College of Qingdao University, 266071, Qingdao, China aut Jiang Hong Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Medical College of Qingdao University, 266071, Qingdao, China aut Xu Huamin Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Medical College of Qingdao University, 266071, Qingdao, China aut Song Ning Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Medical College of Qingdao University, 266071, Qingdao, China aut Xie Junxia Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Medical College of Qingdao University, 266071, Qingdao, China aut Journal of Neural Transmission Springer Vienna 118/3(2011-03-01), 361-369 0300-9564 118:3<361 2011 118 702 https://doi.org/10.1007/s00702-010-0434-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-010-0434-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lv Zhanyun Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Medical College of Qingdao University, 266071, Qingdao, China aut NATIONALLICENCE 700 1- Jiang Hong Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Medical College of Qingdao University, 266071, Qingdao, China aut NATIONALLICENCE 700 1- Xu Huamin Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Medical College of Qingdao University, 266071, Qingdao, China aut NATIONALLICENCE 700 1- Song Ning Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Medical College of Qingdao University, 266071, Qingdao, China aut NATIONALLICENCE 700 1- Xie Junxia Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Medical College of Qingdao University, 266071, Qingdao, China aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/3(2011-03-01), 361-369 0300-9564 118:3<361 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer