caa a22 4500 445376678 CHVBK 20180317143004.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00702-011-0588-7 doi (NATIONALLICENCE)springer-10.1007/s00702-011-0588-7 Iancu Theodore Pediatric Research and Electron Microscopy Unit, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, 34396, Haifa, Israel aut Ultrastructural aspects of iron storage, transport and metabolism [Elektronische Daten] [Theodore Iancu] The iron storage proteins, ferritin and hemosiderin, enable electron microscopic visualization thanks to their electron-dense iron content, which is not present in other compounds involved in transport or metabolism of iron such as transferrin, lactoferrin, or hemoglobin. It is this electron density which contributed to the unraveling of stages in absorption, transport, deposition, storage, and release of iron. In recent years, additional methods of investigation have further supported the information achieved by the ultrastructural studies. Even while using new analytical methods, the seminal morphological observations remain valid for understanding the role of iron in health and disease. In this review, we will illustrate a few basic findings of electron microscopy in humans, experimental animals, and cell cultures. The importance of H chain ferritin as a transporter across the blood-brain barrier is just an example of a new role revealed for an "old” storage protein, explaining some controversial observations on the presence of iron in the brain. Springer-Verlag, 2011 Electron microscopy nationallicence Ultrastructure nationallicence Ferritin nationallicence Hemosiderin nationallicence Lysosomes nationallicence Siderosomes nationallicence Iron overload nationallicence Iron deficiency anemia nationallicence Behavioral disorders nationallicence Parkinson's disease nationallicence Alzheimer's disease nationallicence Iron chelators nationallicence Journal of Neural Transmission Springer Vienna 118/3(2011-03-01), 329-335 0300-9564 118:3<329 2011 118 702 https://doi.org/10.1007/s00702-011-0588-7 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-011-0588-7 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Iancu Theodore Pediatric Research and Electron Microscopy Unit, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, 34396, Haifa, Israel aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/3(2011-03-01), 329-335 0300-9564 118:3<329 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer