caa a22 4500 445376686 CHVBK 20180317143004.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00702-010-0518-0 doi (NATIONALLICENCE)springer-10.1007/s00702-010-0518-0 Iron chelation and neuroprotection in neurodegenerative diseases [Elektronische Daten] [Xuping Li, Joseph Jankovic, Weidong Le] Iron is an essential element for multiple functions of the brain. Maintenance of iron homeostasis involves regulation of iron influx, iron efflux and iron storage. Mismanagement of brain iron has been implicated in neuronal injury and death in several neurodegenerative diseases, such as Parkinson's disease (PD), Alzheimer's disease (PD) and Amyotrophic lateral sclerosis (ALS). Multiple iron chelators have been shown neuroprotective and neurorestorative in these diseases, suggesting that iron chelation might be a promising therapeutics. In this paper, we briefly review the new findings of biological function of several molecules that regulate iron homeostasis in the brain, the possible role of iron mismanagement in the pathogenesis of PD, AD and ALS, and then discuss the putative mechanisms for current available iron chelators as potential therapeutics for neurodegenerative diseases. Springer-Verlag, 2010 Iron chelation nationallicence Neuroprotection nationallicence Parkinson's disease nationallicence Alzheimer's disease nationallicence Amyotrophic lateral sclerosis nationallicence Li Xuping Department of Neurology, Baylor College of Medicine, NB205, One Baylor Plaza, 77030, Houston, TX, USA aut Jankovic Joseph Department of Neurology, Baylor College of Medicine, NB205, One Baylor Plaza, 77030, Houston, TX, USA aut Le Weidong Department of Neurology, Baylor College of Medicine, NB205, One Baylor Plaza, 77030, Houston, TX, USA aut Journal of Neural Transmission Springer Vienna 118/3(2011-03-01), 473-477 0300-9564 118:3<473 2011 118 702 https://doi.org/10.1007/s00702-010-0518-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-010-0518-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Li Xuping Department of Neurology, Baylor College of Medicine, NB205, One Baylor Plaza, 77030, Houston, TX, USA aut NATIONALLICENCE 700 1- Jankovic Joseph Department of Neurology, Baylor College of Medicine, NB205, One Baylor Plaza, 77030, Houston, TX, USA aut NATIONALLICENCE 700 1- Le Weidong Department of Neurology, Baylor College of Medicine, NB205, One Baylor Plaza, 77030, Houston, TX, USA aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/3(2011-03-01), 473-477 0300-9564 118:3<473 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer