caa a22 4500 445376708 CHVBK 20180317143004.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00702-010-0479-3 doi (NATIONALLICENCE)springer-10.1007/s00702-010-0479-3 Iron and the immune system [Elektronische Daten] [Roberta Ward, Robert Crichton, Deanna Taylor, Laura Corte, Surjit Srai, David Dexter] Iron and immunity are closely linked: firstly by the fact that many of the genes/proteins involved in iron homoeostasis play a vital role in controlling iron fluxes such that bacteria are prevented from utilising iron for growth; secondly, cells of the innate immune system, monocytes, macrophages, microglia and lymphocytes, are able to combat bacterial insults by carefully controlling their iron fluxes, which are mediated by hepcidin and ferroportin. In addition, lymphocytes play an important role in adaptive immunity. Thirdly, a variety of effector molecules, e.g. toll-like receptors, NF-κB, hypoxia factor-1, haem oxygenase, will orchestrate the inflammatory response by mobilising a variety of cytokines, neurotrophic factors, chemokines, and reactive oxygen and nitrogen species. Pathologies, where iron loading and depletion occur, may adversely affect the ability of the cell to respond to the bacterial insult. Springer-Verlag, 2010 Macrophage nationallicence Iron nationallicence Hepcidin nationallicence Ferroportin nationallicence Inflammation nationallicence Ward Roberta Biologie du Comportement, Universite Catholique de Louvain, 1348, Louvain-la-Neuve, Belgium aut Crichton Robert IMCN, Universite catholique de Louvain, Louvain-la-Neuve, Belgium aut Taylor Deanna Imperial College, London, UK aut Corte Laura Dipartimento di Farmacologia Preclinica e Clinica, Università degli Studi di Firenze, Florence, Italy aut Srai Surjit University College, London, UK aut Dexter David Imperial College, London, UK aut Journal of Neural Transmission Springer Vienna 118/3(2011-03-01), 315-328 0300-9564 118:3<315 2011 118 702 https://doi.org/10.1007/s00702-010-0479-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-010-0479-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ward Roberta Biologie du Comportement, Universite Catholique de Louvain, 1348, Louvain-la-Neuve, Belgium aut NATIONALLICENCE 700 1- Crichton Robert IMCN, Universite catholique de Louvain, Louvain-la-Neuve, Belgium aut NATIONALLICENCE 700 1- Taylor Deanna Imperial College, London, UK aut NATIONALLICENCE 700 1- Corte Laura Dipartimento di Farmacologia Preclinica e Clinica, Università degli Studi di Firenze, Florence, Italy aut NATIONALLICENCE 700 1- Srai Surjit University College, London, UK aut NATIONALLICENCE 700 1- Dexter David Imperial College, London, UK aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/3(2011-03-01), 315-328 0300-9564 118:3<315 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer