caa a22 4500 445376740 CHVBK 20180317143005.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00702-010-0578-1 doi (NATIONALLICENCE)springer-10.1007/s00702-010-0578-1 Beneficial effect of repetitive transcranial magnetic stimulation combined with cognitive training for the treatment of Alzheimer's disease: a proof of concept study [Elektronische Daten] [Jonathan Bentwich, Evgenia Dobronevsky, Sergio Aichenbaum, Ran Shorer, Ruth Peretz, Michael Khaigrekht, Revital Marton, Jose Rabey] The current drug treatment for Alzheimer's disease (AD) is only partially and temporary effective. Transcranial magnetic stimulation (TMS) is a non-invasive technique that generates an electric current inducing modulation in cortical excitability. In addition, cognitive training (COG) may improve cognitive functions in AD. Our aim was to treat AD patients combining high-frequency repetitive TMS interlaced with COG (rTMS-COG). Eight patients with probable AD, treated for more than 2months with cholinesterase inhibitors, were subjected to daily rTMS-COG sessions (5/week) for 6weeks, followed by maintenance sessions (2/week) for an additional 3months. Six brain regions, located individually by MRI, were stimulated. COG tasks were developed to fit these regions. Primary objectives were average improvement of Alzheimer Disease Assessment Scale-Cognitive (ADAS-cog) and Clinical Global Impression of Change (CGIC) (after 6weeks and 4.5months, compared to baseline). Secondary objectives were average improvement of MMSE, ADAS-ADL, Hamilton Depression Scale (HAMILTON) and Neuropsychiatric Inventory (NPI). One patient abandoned the study after 2months (severe urinary sepsis). ADAS-cog (average) improved by approximately 4 points after both 6weeks and 4.5months of treatment (P<0.01 and P<0.05) and CGIC by 1.0 and 1.6 points, respectively. MMSE, ADAS-ADL and HAMILTON improved, but without statistical significance. NPI did not change. No side effects were recorded. In this study, rTMS-COG (provided by Neuronix Ltd., Yokneam, Israel) seems a promising effective and safe modality for AD treatment, possibly as good as cholinesterase inhibitors. A European double blind study is underway. Springer-Verlag, 2011 rTMS nationallicence Alzheimer's disease nationallicence Cognitive training nationallicence ADAS-cog nationallicence ADAS-ADL nationallicence Bentwich Jonathan Neuronix Ltd, Yokneam, Israel aut Dobronevsky Evgenia Department of Neurology, Assaf Harofeh Medical Center, The Sackler Faculty of Medicine, Tel Aviv University, 70300, Zerifin, Israel aut Aichenbaum Sergio Department of Neurology, Assaf Harofeh Medical Center, The Sackler Faculty of Medicine, Tel Aviv University, 70300, Zerifin, Israel aut Shorer Ran Memory Clinic, Assaf Harofeh Medical Center, The Sackler Faculty of Medicine, Tel Aviv University, 70300, Zerifin, Israel aut Peretz Ruth Memory Clinic, Assaf Harofeh Medical Center, The Sackler Faculty of Medicine, Tel Aviv University, 70300, Zerifin, Israel aut Khaigrekht Michael Memory Clinic, Assaf Harofeh Medical Center, The Sackler Faculty of Medicine, Tel Aviv University, 70300, Zerifin, Israel aut Marton Revital Department of Neurology, Assaf Harofeh Medical Center, The Sackler Faculty of Medicine, Tel Aviv University, 70300, Zerifin, Israel aut Rabey Jose Department of Neurology, Assaf Harofeh Medical Center, The Sackler Faculty of Medicine, Tel Aviv University, 70300, Zerifin, Israel aut Journal of Neural Transmission Springer Vienna 118/3(2011-03-01), 463-471 0300-9564 118:3<463 2011 118 702 https://doi.org/10.1007/s00702-010-0578-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-010-0578-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bentwich Jonathan Neuronix Ltd, Yokneam, Israel aut NATIONALLICENCE 700 1- Dobronevsky Evgenia Department of Neurology, Assaf Harofeh Medical Center, The Sackler Faculty of Medicine, Tel Aviv University, 70300, Zerifin, Israel aut NATIONALLICENCE 700 1- Aichenbaum Sergio Department of Neurology, Assaf Harofeh Medical Center, The Sackler Faculty of Medicine, Tel Aviv University, 70300, Zerifin, Israel aut NATIONALLICENCE 700 1- Shorer Ran Memory Clinic, Assaf Harofeh Medical Center, The Sackler Faculty of Medicine, Tel Aviv University, 70300, Zerifin, Israel aut NATIONALLICENCE 700 1- Peretz Ruth Memory Clinic, Assaf Harofeh Medical Center, The Sackler Faculty of Medicine, Tel Aviv University, 70300, Zerifin, Israel aut NATIONALLICENCE 700 1- Khaigrekht Michael Memory Clinic, Assaf Harofeh Medical Center, The Sackler Faculty of Medicine, Tel Aviv University, 70300, Zerifin, Israel aut NATIONALLICENCE 700 1- Marton Revital Department of Neurology, Assaf Harofeh Medical Center, The Sackler Faculty of Medicine, Tel Aviv University, 70300, Zerifin, Israel aut NATIONALLICENCE 700 1- Rabey Jose Department of Neurology, Assaf Harofeh Medical Center, The Sackler Faculty of Medicine, Tel Aviv University, 70300, Zerifin, Israel aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/3(2011-03-01), 463-471 0300-9564 118:3<463 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer