caa a22 4500 445376767 CHVBK 20180317143005.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00702-011-0582-0 doi (NATIONALLICENCE)springer-10.1007/s00702-011-0582-0 A possible role for secreted ferritin in tissue iron distribution [Elektronische Daten] [Esther Meyron-Holtz, Shirly Moshe-Belizowski, Lyora Cohen] Ferritin is known as a well-conserved iron detoxification and storage protein that is found in the cytosol of many prokaryotic and eukaryotic organisms. In insects and worms, ferritin has evolved into a classically secreted protein that transports iron systemically. Mammalian ferritins are found intracellularly in the cytosol, as well as in the nucleus, the endo-lysosomal compartment and the mitochondria. Extracellular ferritin is found in fluids such as serum and synovial and cerebrospinal fluids. We recently characterized the biophysical properties, secretion mechanism and cellular origin of mouse serum ferritin, which is actively secreted by a non-classical pathway involving lysosomal processing. Here, we review the data to support a hypothesis that intracellular and extracellular ferritin may play a role in intra- and intercellular redistribution of iron. Springer-Verlag, 2011 Extracellular ferritin nationallicence Iron trafficking nationallicence Serum ferritin nationallicence Secretory lysosome nationallicence Meyron-Holtz Esther Laboratory for Molecular Nutrition, Faculty of Biotechnology and Food Engineering, Technion, 32000, Technion City, Haifa, Israel aut Moshe-Belizowski Shirly Laboratory for Molecular Nutrition, Faculty of Biotechnology and Food Engineering, Technion, 32000, Technion City, Haifa, Israel aut Cohen Lyora Laboratory for Molecular Nutrition, Faculty of Biotechnology and Food Engineering, Technion, 32000, Technion City, Haifa, Israel aut Journal of Neural Transmission Springer Vienna 118/3(2011-03-01), 337-347 0300-9564 118:3<337 2011 118 702 https://doi.org/10.1007/s00702-011-0582-0 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-011-0582-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Meyron-Holtz Esther Laboratory for Molecular Nutrition, Faculty of Biotechnology and Food Engineering, Technion, 32000, Technion City, Haifa, Israel aut NATIONALLICENCE 700 1- Moshe-Belizowski Shirly Laboratory for Molecular Nutrition, Faculty of Biotechnology and Food Engineering, Technion, 32000, Technion City, Haifa, Israel aut NATIONALLICENCE 700 1- Cohen Lyora Laboratory for Molecular Nutrition, Faculty of Biotechnology and Food Engineering, Technion, 32000, Technion City, Haifa, Israel aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/3(2011-03-01), 337-347 0300-9564 118:3<337 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer