caa a22 4500 445376848 CHVBK 20180317143005.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00702-010-0436-1 doi (NATIONALLICENCE)springer-10.1007/s00702-010-0436-1 Schipper Hyman Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Cote St. Catherine Road, H3T 1E2, Montreal, QC, Canada aut Heme oxygenase-1 in Alzheimer disease: a tribute to Moussa Youdim [Elektronische Daten] [Hyman Schipper] Heme oxygenase-1 (HO-1), a 32kDa stress protein mediating the degradation of heme to ferrous iron, carbon monoxide and biliverdin/bilirubin, has been implicated in the pathogenesis of Alzheimer disease (AD) and other aging-related neurodegenerative disorders. In AD and mild cognitive impairment (MCI), immunoreactive HO-1 protein is over-expressed in astrocytes and neurons of the hippocampus and cerebral cortex and co-localizes to neurofibrillary tangles, senile plaques and corpora amylacea. Astroglial induction of the Hmox1 gene by β-amyloid, pro-inflammatory cytokines and hydrogen peroxide promotes mitochondrial sequestration of non-transferrin iron and macroautophagy and may thereby contribute to the pathological iron deposition and bioenergy failure amply documented in AD-affected neural tissues. Glial HO-1 expression may also impact cell survival and neuroplasticity in AD by modulating brain sterol/oxysterol metabolism and the degradation of tau by the proteasome. Suppression of glial HO-1 activity by pharmacological or other means may confer neuroprotection in AD by curtailing iron-mediated neurotoxicity. Springer-Verlag, 2010 Alzheimer disease nationallicence Heme oxygenase-1 nationallicence Iron nationallicence Mild cognitive impairment nationallicence Mitochondria nationallicence Oxidative stress nationallicence Journal of Neural Transmission Springer Vienna 118/3(2011-03-01), 381-387 0300-9564 118:3<381 2011 118 702 https://doi.org/10.1007/s00702-010-0436-1 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-010-0436-1 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Schipper Hyman Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Cote St. Catherine Road, H3T 1E2, Montreal, QC, Canada aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/3(2011-03-01), 381-387 0300-9564 118:3<381 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer