caa a22 4500 445376856 CHVBK 20180317143005.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00702-011-0639-0 doi (NATIONALLICENCE)springer-10.1007/s00702-011-0639-0 Targeting of the pedunculopontine nucleus by an MRI-guided approach: a cadaver study [Elektronische Daten] [Ludvic Zrinzo, Laurence Zrinzo, Luke Massey, John Thornton, Harold Parkes, Mark White, Tarek Yousry, Catherine Strand, Tamas Revesz, Patricia Limousin, Marwan Hariz, Janice Holton] Laboratory evidence suggests that the pedunculopontine nucleus (PPN) plays a central role in the initiation and maintenance of gait. Translational research has led to reports on deep brain stimulation (DBS) of the rostral brainstem in parkinsonian patients. However, initial clinical results appear to be rather variable. Possible factors include patient selection and the wide variability in anatomical location of implanted electrodes. Clinical studies on PPN DBS efficacy would, therefore, benefit from an accurate and reproducible method of stereotactic localization of the nucleus. The present study evaluates the anatomical accuracy of a specific protocol for MRI-guided stereotactic targeting of the PPN in a human cadaver. Imaging at 1.5 and 9.4T confirmed electrode location in the intended region as defined anatomically by the surrounding fiber tracts. The spatial relations of each electrode track to the nucleus were explored by subsequent histological examination. This confirmed that the neuropil surrounding each electrode track contained scattered large neurons morphologically consistent with those of the subnucleus dissipatus and compactus of the PPN. The results support the accuracy of the described specific MR imaging protocol. Springer-Verlag, 2011 Pedunculopontine nucleus nationallicence MRI nationallicence Stereotactic nationallicence Deep brain stimulation nationallicence Zrinzo Ludvic Unit of Functional Neurosurgery, Box 146, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, WC1N 3BG, London, UK aut Zrinzo Laurence Department of Anatomy, Genetics and Cell Biology, University of Malta, 2080, Msida, Malta aut Massey Luke Sara Koe PSP Research Centre, UCL Institute of Neurology, 1 Wakefield Street, WC1N 1PJ, London, UK aut Thornton John Lysholm Department of Neuroradiology, UCL Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, WC1N 3BG, London, UK aut Parkes Harold Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, University College London, Queen Square, WC1N 3BG, London, UK aut White Mark Lysholm Department of Neuroradiology, UCL Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, WC1N 3BG, London, UK aut Yousry Tarek Lysholm Department of Neuroradiology, UCL Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, WC1N 3BG, London, UK aut Strand Catherine Queen Square Brain Bank, Department of Molecular Neuroscience, UCL Institute of Neurology, 1 Wakefield Street, WC1N 1PJ, London, UK aut Revesz Tamas Queen Square Brain Bank, Department of Molecular Neuroscience, UCL Institute of Neurology, 1 Wakefield Street, WC1N 1PJ, London, UK aut Limousin Patricia Unit of Functional Neurosurgery, Box 146, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, WC1N 3BG, London, UK aut Hariz Marwan Unit of Functional Neurosurgery, Box 146, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, WC1N 3BG, London, UK aut Holton Janice Queen Square Brain Bank, Department of Molecular Neuroscience, UCL Institute of Neurology, 1 Wakefield Street, WC1N 1PJ, London, UK aut Journal of Neural Transmission Springer Vienna 118/10(2011-10-01), 1487-1495 0300-9564 118:10<1487 2011 118 702 https://doi.org/10.1007/s00702-011-0639-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-011-0639-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zrinzo Ludvic Unit of Functional Neurosurgery, Box 146, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, WC1N 3BG, London, UK aut NATIONALLICENCE 700 1- Zrinzo Laurence Department of Anatomy, Genetics and Cell Biology, University of Malta, 2080, Msida, Malta aut NATIONALLICENCE 700 1- Massey Luke Sara Koe PSP Research Centre, UCL Institute of Neurology, 1 Wakefield Street, WC1N 1PJ, London, UK aut NATIONALLICENCE 700 1- Thornton John Lysholm Department of Neuroradiology, UCL Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, WC1N 3BG, London, UK aut NATIONALLICENCE 700 1- Parkes Harold Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, University College London, Queen Square, WC1N 3BG, London, UK aut NATIONALLICENCE 700 1- White Mark Lysholm Department of Neuroradiology, UCL Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, WC1N 3BG, London, UK aut NATIONALLICENCE 700 1- Yousry Tarek Lysholm Department of Neuroradiology, UCL Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, WC1N 3BG, London, UK aut NATIONALLICENCE 700 1- Strand Catherine Queen Square Brain Bank, Department of Molecular Neuroscience, UCL Institute of Neurology, 1 Wakefield Street, WC1N 1PJ, London, UK aut NATIONALLICENCE 700 1- Revesz Tamas Queen Square Brain Bank, Department of Molecular Neuroscience, UCL Institute of Neurology, 1 Wakefield Street, WC1N 1PJ, London, UK aut NATIONALLICENCE 700 1- Limousin Patricia Unit of Functional Neurosurgery, Box 146, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, WC1N 3BG, London, UK aut NATIONALLICENCE 700 1- Hariz Marwan Unit of Functional Neurosurgery, Box 146, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, WC1N 3BG, London, UK aut NATIONALLICENCE 700 1- Holton Janice Queen Square Brain Bank, Department of Molecular Neuroscience, UCL Institute of Neurology, 1 Wakefield Street, WC1N 1PJ, London, UK aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/10(2011-10-01), 1487-1495 0300-9564 118:10<1487 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer