caa a22 4500 445376864 CHVBK 20180317143005.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00702-010-0500-x doi (NATIONALLICENCE)springer-10.1007/s00702-010-0500-x The pedunculopontine tegmental nucleus: from basic neuroscience to neurosurgical applications [Elektronische Daten] Arousal from slices to humans: implications for DBS [Edgar Garcia-Rill, Christen Simon, Kristen Smith, Nebosja Kezunovic, James Hyde] One element of the reticular activating system (RAS) is the pedunculopontine nucleus (PPN), which projects to the thalamus to trigger thalamocortical rhythms and the brainstem to modulate muscle tone and locomotion. The PPN is a posterior midbrain site known to induce locomotion in decerebrate animals when activated at 40-60Hz, and has become a target for DBS in disorders involving gait deficits. We developed a research program using brainstem slices containing the PPN to study the cellular and molecular organization of this region. We showed that PPN neurons preferentially fire at gamma band frequency (30-60Hz) when maximally activated, accounting for the effects of electrical stimulation. In addition, we developed the P13 midlatency auditory evoked potential, which is generated by PPN outputs, in freely moving rats. This allows the study of PPN cellular and molecular mechanisms in the whole animal. We also study the P50 midlatency auditory evoked potential, which is the human equivalent of the rodent P13 potential, allowing us to study PPN-related processes detected in vitro, confirmed in the whole animal, and tested in humans. Previous findings on the P50 potential in PD suggest that PPN output in this disorder is overactive. This translational research program led to the discovery of a novel mechanism of sleep-wake control based on electrical coupling, pointing the way to a number of new clinical applications in the development of novel stimulants (e.g., modafinil) and anesthetics. In addition, it provides methods for monitoring therapeutic efficacy of DBS in humans and animal models. Springer-Verlag, 2010 Arousal nationallicence Electrical coupling nationallicence Gamma band activity nationallicence Locomotion nationallicence Modafinil nationallicence Pedunculopontine nucleus nationallicence Garcia-Rill Edgar Department of Neurobiology and Developmental Science, Center For Translational Neuroscience, University of Arkansas for Medical Sciences, 4301 West Markham St., Slot 847, 72205, Little Rock, AR, USA aut Simon Christen Department of Neurobiology and Developmental Science, Center For Translational Neuroscience, University of Arkansas for Medical Sciences, 4301 West Markham St., Slot 847, 72205, Little Rock, AR, USA aut Smith Kristen Department of Neurobiology and Developmental Science, Center For Translational Neuroscience, University of Arkansas for Medical Sciences, 4301 West Markham St., Slot 847, 72205, Little Rock, AR, USA aut Kezunovic Nebosja Department of Neurobiology and Developmental Science, Center For Translational Neuroscience, University of Arkansas for Medical Sciences, 4301 West Markham St., Slot 847, 72205, Little Rock, AR, USA aut Hyde James Department of Neurobiology and Developmental Science, Center For Translational Neuroscience, University of Arkansas for Medical Sciences, 4301 West Markham St., Slot 847, 72205, Little Rock, AR, USA aut Journal of Neural Transmission Springer Vienna 118/10(2011-10-01), 1397-1407 0300-9564 118:10<1397 2011 118 702 https://doi.org/10.1007/s00702-010-0500-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-010-0500-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Garcia-Rill Edgar Department of Neurobiology and Developmental Science, Center For Translational Neuroscience, University of Arkansas for Medical Sciences, 4301 West Markham St., Slot 847, 72205, Little Rock, AR, USA aut NATIONALLICENCE 700 1- Simon Christen Department of Neurobiology and Developmental Science, Center For Translational Neuroscience, University of Arkansas for Medical Sciences, 4301 West Markham St., Slot 847, 72205, Little Rock, AR, USA aut NATIONALLICENCE 700 1- Smith Kristen Department of Neurobiology and Developmental Science, Center For Translational Neuroscience, University of Arkansas for Medical Sciences, 4301 West Markham St., Slot 847, 72205, Little Rock, AR, USA aut NATIONALLICENCE 700 1- Kezunovic Nebosja Department of Neurobiology and Developmental Science, Center For Translational Neuroscience, University of Arkansas for Medical Sciences, 4301 West Markham St., Slot 847, 72205, Little Rock, AR, USA aut NATIONALLICENCE 700 1- Hyde James Department of Neurobiology and Developmental Science, Center For Translational Neuroscience, University of Arkansas for Medical Sciences, 4301 West Markham St., Slot 847, 72205, Little Rock, AR, USA aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/10(2011-10-01), 1397-1407 0300-9564 118:10<1397 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer