caa a22 4500 445376880 CHVBK 20180317143005.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00702-011-0644-3 doi (NATIONALLICENCE)springer-10.1007/s00702-011-0644-3 Neurophysiological evaluation of the pedunculopontine nucleus in humans [Elektronische Daten] [P. Profice, P. Mazzone, F. Pilato, M. Dileone, A. Insola, F. Ranieri, V. Di Lazzaro] The pedunculopontine nucleus (PPTg) is constituted by a heterogeneous cluster of neurons located in caudal mesencephalic tegmentum which projects to the thalamus to trigger thalamocortical rhythms and the brainstem to modulate muscle tone and locomotion. It has been investigated as potential deep brain stimulation (DBS) target for treating Parkinson's disease (PD) symptoms. Neurophysiological studies conducted in humans using DBS electrodes for exploring functional properties of PPTg in vivo, reviewed in this paper, demonstrated that the functional connections between PPTg and cortex, basal ganglia, brainstem network involved in sleep/wake control, and spinal cord can be explored in vivo and provided useful insights about the physiology of this nucleus and pathophysiology of PD. Springer-Verlag, 2011 Pedunculopontine nucleus nationallicence Deep brain stimulation nationallicence Parkinson's disease nationallicence Profice P. Institute of Neurology, Università Cattolica, L.go A. Gemelli 8, 00168, Rome, Italy aut Mazzone P. Neurochirurgia CTO, Via S. Nemesio 21, 00145, Rome, Italy aut Pilato F. Institute of Neurology, Università Cattolica, L.go A. Gemelli 8, 00168, Rome, Italy aut Dileone M. Institute of Neurology, Università Cattolica, L.go A. Gemelli 8, 00168, Rome, Italy aut Insola A. Neurofisiologia CTO, Via S. Nemesio 21, 00145, Rome, Italy aut Ranieri F. Institute of Neurology, Università Cattolica, L.go A. Gemelli 8, 00168, Rome, Italy aut Di Lazzaro V. Institute of Neurology, Università Cattolica, L.go A. Gemelli 8, 00168, Rome, Italy aut Journal of Neural Transmission Springer Vienna 118/10(2011-10-01), 1423-1429 0300-9564 118:10<1423 2011 118 702 https://doi.org/10.1007/s00702-011-0644-3 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-011-0644-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Profice P. Institute of Neurology, Università Cattolica, L.go A. Gemelli 8, 00168, Rome, Italy aut NATIONALLICENCE 700 1- Mazzone P. Neurochirurgia CTO, Via S. Nemesio 21, 00145, Rome, Italy aut NATIONALLICENCE 700 1- Pilato F. Institute of Neurology, Università Cattolica, L.go A. Gemelli 8, 00168, Rome, Italy aut NATIONALLICENCE 700 1- Dileone M. Institute of Neurology, Università Cattolica, L.go A. Gemelli 8, 00168, Rome, Italy aut NATIONALLICENCE 700 1- Insola A. Neurofisiologia CTO, Via S. Nemesio 21, 00145, Rome, Italy aut NATIONALLICENCE 700 1- Ranieri F. Institute of Neurology, Università Cattolica, L.go A. Gemelli 8, 00168, Rome, Italy aut NATIONALLICENCE 700 1- Di Lazzaro V. Institute of Neurology, Università Cattolica, L.go A. Gemelli 8, 00168, Rome, Italy aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/10(2011-10-01), 1423-1429 0300-9564 118:10<1423 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer