caa a22 4500 445376899 CHVBK 20180317143005.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00702-011-0705-7 doi (NATIONALLICENCE)springer-10.1007/s00702-011-0705-7 Effects of unilateral pedunculopontine stimulation on electromyographic activation patterns during gait in individual patients with Parkinson's disease [Elektronische Daten] [Pietro Caliandro, A. Insola, E. Scarnati, L. Padua, G. Russo, E. Granieri, P. Mazzone] In Parkinson's disease (PD), the effects of deep brain stimulation of the pedunculopontine nucleus (PPTg-DBS) on gait has been object of international debate. Some evidence demonstrated that, in the late swing-early stance phase of gait cycle, a reduced surface electromyographic activation (sEMG) of tibialis anterior (TA) is linked to the striatal dopamine deficiency in PD patients. In the present study we report preliminary results on the effect of PPTg-DBS on electromyographic patterns during gait in individual PD patients. To evaluate the sEMG amplitude of TA, the root mean square (RMS) of the TA burst in late swing-early stance phase (RMS-A) was normalized as a percent of the RMS of the TA burst in late stance-early swing (RMS-B). We studied three male patients in the following conditions: on PPTg-DBS/on l-dopa, on PPTg-DBS/off l-dopa, off PPTg-DBS/on l-dopa, off PPTg-DBS/off l-dopa. For each assessment the UPDRS III was filled in. We observed no difference between on PPTg-DBS/off l-dopa and off PPTg-DBS/off l-dopa in UPDRS III scores. In off PPTg-DBS/off l-dopa, patient A (right implant) showed absence of the right and left RMSA, respectively, in 80% and 83% of gait cycles. Patient B (right implant) showed absence of the right RMS-A in 86% of cycles. RMS-A of the patient C (left implant) was bilaterally normal. In on PPTg- DBS/off l-dopa, no patient showed reduced RMS-A. Although the very low number of subjects we evaluated, our observations suggest that PPTg plays a role in modulating TA activation pattern during the steady state of gait. Springer-Verlag, 2011 Parkinson's disease nationallicence Pedunculopontine nucleus nationallicence Gait nationallicence Deep brain stimulation nationallicence Caliandro Pietro Department of Neuroscience, Institute of Neurology, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168, Rome, Italy aut Insola A. Unità Operativa di Neurofisiopatologia, CTO, ASL RMC, Rome, Italy aut Scarnati E. Department of Sciences and Biomedical Technologies, University of L'Aquila, L'Aquila, Italy aut Padua L. Department of Neuroscience, Institute of Neurology, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168, Rome, Italy aut Russo G. Fondazione Don Carlo Gnocchi Onlus, Milan, Italy aut Granieri E. Department of Medical Surgical Sciences of Communication and Behaviour, Section of Neurology, University of Ferrara, Ferrara, Italy aut Mazzone P. Functional and Stereotactic Neurosurgery, CTO, ASL RMC, Rome, Italy aut Journal of Neural Transmission Springer Vienna 118/10(2011-10-01), 1477-1486 0300-9564 118:10<1477 2011 118 702 https://doi.org/10.1007/s00702-011-0705-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-011-0705-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Caliandro Pietro Department of Neuroscience, Institute of Neurology, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168, Rome, Italy aut NATIONALLICENCE 700 1- Insola A. Unità Operativa di Neurofisiopatologia, CTO, ASL RMC, Rome, Italy aut NATIONALLICENCE 700 1- Scarnati E. Department of Sciences and Biomedical Technologies, University of L'Aquila, L'Aquila, Italy aut NATIONALLICENCE 700 1- Padua L. Department of Neuroscience, Institute of Neurology, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168, Rome, Italy aut NATIONALLICENCE 700 1- Russo G. Fondazione Don Carlo Gnocchi Onlus, Milan, Italy aut NATIONALLICENCE 700 1- Granieri E. Department of Medical Surgical Sciences of Communication and Behaviour, Section of Neurology, University of Ferrara, Ferrara, Italy aut NATIONALLICENCE 700 1- Mazzone P. Functional and Stereotactic Neurosurgery, CTO, ASL RMC, Rome, Italy aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/10(2011-10-01), 1477-1486 0300-9564 118:10<1477 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer