caa a22 4500 445376961 CHVBK 20180317143005.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00702-011-0656-z doi (NATIONALLICENCE)springer-10.1007/s00702-011-0656-z Deep brain stimulation for movement disorders. Considerations on 276 consecutive patients [Elektronische Daten] [Angelo Franzini, Roberto Cordella, Giuseppe Messina, Carlo Marras, Luigi Romito, Francesco Carella, Alberto Albanese, Michele Rizzi, Nardo Nardocci, Giovanna Zorzi, Edvin Zekay, Giovanni Broggi] The links between Stn DBS and advanced Parkinson disease, and between GPi DBS and dystonia are nearly universally accepted by the neurologists and neurosurgeons. Nevertheless, in some conditions, targets such as the ventral thalamus and the Zona Incerta may be considered to optimize the results and avoid the side effects. Positive and negative aspects of current DBS treatments justify the research of new targets, new stimulation programs and new hardware. Since 1993, at the Istituto Nazionale Neurologico "Carlo Besta” in Milan, 580 deep brain electrodes were implanted in 332 patients. 276 patients were affected by movement disorders. The DBS targets included Stn, GPi, Voa, Vop, Vim, CM-pf, cZi, IC. The long-term follow-up is reported and related to the chosen target. DBS gave a new therapeutic option to patients affected by severe movement disorders, and in some cases resolved life-threatening pathological conditions that would otherwise result in the death of the patient, such as in status dystonicus, and post-stroke hemiballismus. Nevertheless, the potential occurrence of severe complications still limit a wider use of DBS. At today, the use of DBS in severe movement disorders is strongly positive even if further investigations and studies are needed to unveil potential new applications, and to refine the selection criteria for the actual indications and targets. The experience of different targets may be useful to guide and tailor the target choice to the individual clinical condition. Springer-Verlag, 2011 Deep brain stimulation nationallicence Movement disorders nationallicence Franzini Angelo Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico "C. Besta”, Via Celoria 11, 20133, Milan, Italy aut Cordella Roberto Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico "C. Besta”, Via Celoria 11, 20133, Milan, Italy aut Messina Giuseppe Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico "C. Besta”, Via Celoria 11, 20133, Milan, Italy aut Marras Carlo Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico "C. Besta”, Via Celoria 11, 20133, Milan, Italy aut Romito Luigi Department of Neurology, Fondazione IRCCS Istituto Neurologico "C. Besta”, Via Celoria 11, 20133, Milan, Italy aut Carella Francesco Department of Neurology, Fondazione IRCCS Istituto Neurologico "C. Besta”, Via Celoria 11, 20133, Milan, Italy aut Albanese Alberto Department of Neurology, Fondazione IRCCS Istituto Neurologico "C. Besta”, Via Celoria 11, 20133, Milan, Italy aut Rizzi Michele Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico "C. Besta”, Via Celoria 11, 20133, Milan, Italy aut Nardocci Nardo Department of Child Neurology, Fondazione IRCCS Istituto Neurologico "C. Besta”, Via Celoria 11, 20133, Milan, Italy aut Zorzi Giovanna Department of Child Neurology, Fondazione IRCCS Istituto Neurologico "C. Besta”, Via Celoria 11, 20133, Milan, Italy aut Zekay Edvin Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico "C. Besta”, Via Celoria 11, 20133, Milan, Italy aut Broggi Giovanni Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico "C. Besta”, Via Celoria 11, 20133, Milan, Italy aut Journal of Neural Transmission Springer Vienna 118/10(2011-10-01), 1497-1510 0300-9564 118:10<1497 2011 118 702 https://doi.org/10.1007/s00702-011-0656-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-011-0656-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Franzini Angelo Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico "C. Besta”, Via Celoria 11, 20133, Milan, Italy aut NATIONALLICENCE 700 1- Cordella Roberto Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico "C. Besta”, Via Celoria 11, 20133, Milan, Italy aut NATIONALLICENCE 700 1- Messina Giuseppe Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico "C. Besta”, Via Celoria 11, 20133, Milan, Italy aut NATIONALLICENCE 700 1- Marras Carlo Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico "C. Besta”, Via Celoria 11, 20133, Milan, Italy aut NATIONALLICENCE 700 1- Romito Luigi Department of Neurology, Fondazione IRCCS Istituto Neurologico "C. Besta”, Via Celoria 11, 20133, Milan, Italy aut NATIONALLICENCE 700 1- Carella Francesco Department of Neurology, Fondazione IRCCS Istituto Neurologico "C. Besta”, Via Celoria 11, 20133, Milan, Italy aut NATIONALLICENCE 700 1- Albanese Alberto Department of Neurology, Fondazione IRCCS Istituto Neurologico "C. Besta”, Via Celoria 11, 20133, Milan, Italy aut NATIONALLICENCE 700 1- Rizzi Michele Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico "C. Besta”, Via Celoria 11, 20133, Milan, Italy aut NATIONALLICENCE 700 1- Nardocci Nardo Department of Child Neurology, Fondazione IRCCS Istituto Neurologico "C. Besta”, Via Celoria 11, 20133, Milan, Italy aut NATIONALLICENCE 700 1- Zorzi Giovanna Department of Child Neurology, Fondazione IRCCS Istituto Neurologico "C. Besta”, Via Celoria 11, 20133, Milan, Italy aut NATIONALLICENCE 700 1- Zekay Edvin Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico "C. Besta”, Via Celoria 11, 20133, Milan, Italy aut NATIONALLICENCE 700 1- Broggi Giovanni Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico "C. Besta”, Via Celoria 11, 20133, Milan, Italy aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/10(2011-10-01), 1497-1510 0300-9564 118:10<1497 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer