caa a22 4500 445377046 CHVBK 20180317143006.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00702-010-0535-z doi (NATIONALLICENCE)springer-10.1007/s00702-010-0535-z Is C-reactive protein level a marker of advanced motor and neuropsychiatric complications in Parkinson's disease? [Elektronische Daten] [Sharon Hassin-Baer, Oren Cohen, Eli Vakil, Noa Molshazki, Ben-Ami Sela, Zeev Nitsan, Joab Chapman, David Tanne] C-reactive protein (CRP) is a plasma protein involved in inflammation. While its levels have been associated with stroke, cognitive impairment and depression, the association with clinical characteristics of Parkinson's disease (PD) is unknown. A total of 73 consecutive patients with PD (46 males, age 68.8±11.5years) were evaluated regarding motor as well as cognitive and psychiatric features of PD. Plasma CRP levels were determined and tests for associations with disease parameters were performed. The average level of CRP was 3.9±4.1μmol/L, and 45.2% of the patients (n=33) had a level above 3.0μmol/L. Patients in the high CRP group tended to be older (71.4±9.2 vs. 66.7±12.9years; p=0.08) and coronary artery disease (CAD) was more common (36 vs. 10%, p<0.05) in the high CRP group, but no differences were found between the groups regarding gender, disease duration, levodopa dose, motor scores or most of the neuropsychiatric complications such as severity of depression, psychosis, dementia, cognitive decline or frontal lobe dysfunction. Reported depression (at present or in the past) was more common in the high CRP group (54.5 vs. 25%, p=0.01). CRP levels in patients with PD are associated with a higher prevalence of CAD, but are not associated with PD duration or severity, or with neuropsychiatric complications other than reported depression. Springer-Verlag, 2010 Parkinson's disease nationallicence Inflammation nationallicence C-reactive protein nationallicence Risk factor nationallicence Neuropsychiatric complications nationallicence Hassin-Baer Sharon Department of Neurology, Chaim Sheba Medical Center, 52621, Tel Hashomer, Israel aut Cohen Oren Department of Neurology, Chaim Sheba Medical Center, 52621, Tel Hashomer, Israel aut Vakil Eli Department of Psychology, Bar Ilan University, Ramat-Gan, Israel aut Molshazki Noa Sagol Neuroscience Center, Chaim Sheba Medical Center, Tel Hashomer, Israel aut Sela Ben-Ami Institute of Chemical Pathology, Chaim Sheba Medical Center, Tel Hashomer, Israel aut Nitsan Zeev Department of Neurology, Chaim Sheba Medical Center, 52621, Tel Hashomer, Israel aut Chapman Joab Department of Neurology, Chaim Sheba Medical Center, 52621, Tel Hashomer, Israel aut Tanne David Department of Neurology, Chaim Sheba Medical Center, 52621, Tel Hashomer, Israel aut Journal of Neural Transmission Springer Vienna 118/4(2011-04-01), 539-543 0300-9564 118:4<539 2011 118 702 https://doi.org/10.1007/s00702-010-0535-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-010-0535-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hassin-Baer Sharon Department of Neurology, Chaim Sheba Medical Center, 52621, Tel Hashomer, Israel aut NATIONALLICENCE 700 1- Cohen Oren Department of Neurology, Chaim Sheba Medical Center, 52621, Tel Hashomer, Israel aut NATIONALLICENCE 700 1- Vakil Eli Department of Psychology, Bar Ilan University, Ramat-Gan, Israel aut NATIONALLICENCE 700 1- Molshazki Noa Sagol Neuroscience Center, Chaim Sheba Medical Center, Tel Hashomer, Israel aut NATIONALLICENCE 700 1- Sela Ben-Ami Institute of Chemical Pathology, Chaim Sheba Medical Center, Tel Hashomer, Israel aut NATIONALLICENCE 700 1- Nitsan Zeev Department of Neurology, Chaim Sheba Medical Center, 52621, Tel Hashomer, Israel aut NATIONALLICENCE 700 1- Chapman Joab Department of Neurology, Chaim Sheba Medical Center, 52621, Tel Hashomer, Israel aut NATIONALLICENCE 700 1- Tanne David Department of Neurology, Chaim Sheba Medical Center, 52621, Tel Hashomer, Israel aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/4(2011-04-01), 539-543 0300-9564 118:4<539 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer