caa a22 4500 445377070 CHVBK 20180317143006.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00702-010-0551-z doi (NATIONALLICENCE)springer-10.1007/s00702-010-0551-z Screening for anorexia nervosa via measurement of serum leptin levels [Elektronische Daten] [M. Föcker, N. Timmesfeld, S. Scherag, K. Bühren, M. Langkamp, A. Dempfle, E. Sheridan, M. de Zwaan, C. Fleischhaker, W. Herzog, K. Egberts, S. Zipfel, B. Herpertz-Dahlmann, J. Hebebrand] Due to their sub-normally low fat mass, leptin levels in patients with acute anorexia nervosa (AN) are well below reference levels for age and sex-matched controls. This hypoleptinemia entails endocrinological and behavioral characteristics observed in AN patients during starvation. We aimed to study the appropriateness of hypoleptinemia as a diagnostic marker for AN by assessing sensitivity, specificity and likelihood ratios for different referral serum leptin levels for predicting anorexia nervosa and healthy leanness. For prediction, we additionally generated a score based on a multivariate logistic model including body mass index (BMI; kg/m²) and leptin level. For this purpose, we measured leptin levels in 74 female patients with acute AN upon admission for inpatient or outpatient treatment. Adolescent and adult patients were recruited according to DSM-IV criteria from two multi-center studies. Additionally, leptin levels were measured in 65 female healthy, lean students. Mean serum leptin level was significantly decreased in patients with AN compared to underweight controls (0.87±0.90 vs. 6.43±3.55μg/L, p<0.001). Leptin predicted AN independently of BMI; we confirmed a cutoff value in the range of 2μg/L as having both high specificity and sensitivity. Hypoleptinemia represents a state marker of acute AN and is useful for a laboratory-based diagnostic screening. Springer-Verlag, 2011 Anorexia nervosa nationallicence Hypoleptinemia nationallicence Leptin threshold nationallicence Screening nationallicence State marker nationallicence Föcker M. Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg-Essen, Virchowstr. 174, 45147, Essen, Germany aut Timmesfeld N. Institute of Medical Biometry and Epidemiology, Philipps-University, Marburg, Germany aut Scherag S. Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg-Essen, Virchowstr. 174, 45147, Essen, Germany aut Bühren K. Department of Child and Adolescent Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany aut Langkamp M. Mediagnost, Reutlingen, Germany aut Dempfle A. Institute of Medical Biometry and Epidemiology, Philipps-University, Marburg, Germany aut Sheridan E. The Zucker Hillside Hospital, Psychiatry Research, Glen Oaks, NY, USA aut de Zwaan M. Department of Psychosomatic Medicine and Psychotherapy, University Hospital of Erlangen, Erlangen, Germany aut Fleischhaker C. Department of Child and Adolescent Psychiatry and Psychotherapy, University of Freiburg, Freiburg, Germany aut Herzog W. Department of Psychosomatic and General Internal Medicine, Centre for Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany aut Egberts K. Department of Child and Adolescent Psychiatry and Psychotherapy, University of Würzburg, Würzburg, Germany aut Zipfel S. Department of Psychosomatic Medicine and Psychotherapy, Medical University Hospital Tübingen, University Tübingen, Tübingen, Germany aut Herpertz-Dahlmann B. Department of Child and Adolescent Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany aut Hebebrand J. Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg-Essen, Virchowstr. 174, 45147, Essen, Germany aut Journal of Neural Transmission Springer Vienna 118/4(2011-04-01), 571-578 0300-9564 118:4<571 2011 118 702 https://doi.org/10.1007/s00702-010-0551-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-010-0551-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Föcker M. Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg-Essen, Virchowstr. 174, 45147, Essen, Germany aut NATIONALLICENCE 700 1- Timmesfeld N. Institute of Medical Biometry and Epidemiology, Philipps-University, Marburg, Germany aut NATIONALLICENCE 700 1- Scherag S. Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg-Essen, Virchowstr. 174, 45147, Essen, Germany aut NATIONALLICENCE 700 1- Bühren K. Department of Child and Adolescent Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany aut NATIONALLICENCE 700 1- Langkamp M. Mediagnost, Reutlingen, Germany aut NATIONALLICENCE 700 1- Dempfle A. Institute of Medical Biometry and Epidemiology, Philipps-University, Marburg, Germany aut NATIONALLICENCE 700 1- Sheridan E. The Zucker Hillside Hospital, Psychiatry Research, Glen Oaks, NY, USA aut NATIONALLICENCE 700 1- de Zwaan M. Department of Psychosomatic Medicine and Psychotherapy, University Hospital of Erlangen, Erlangen, Germany aut NATIONALLICENCE 700 1- Fleischhaker C. Department of Child and Adolescent Psychiatry and Psychotherapy, University of Freiburg, Freiburg, Germany aut NATIONALLICENCE 700 1- Herzog W. Department of Psychosomatic and General Internal Medicine, Centre for Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany aut NATIONALLICENCE 700 1- Egberts K. Department of Child and Adolescent Psychiatry and Psychotherapy, University of Würzburg, Würzburg, Germany aut NATIONALLICENCE 700 1- Zipfel S. Department of Psychosomatic Medicine and Psychotherapy, Medical University Hospital Tübingen, University Tübingen, Tübingen, Germany aut NATIONALLICENCE 700 1- Herpertz-Dahlmann B. Department of Child and Adolescent Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany aut NATIONALLICENCE 700 1- Hebebrand J. Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg-Essen, Virchowstr. 174, 45147, Essen, Germany aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/4(2011-04-01), 571-578 0300-9564 118:4<571 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer