caa a22 4500 445377119 CHVBK 20180317143006.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00702-010-0553-x doi (NATIONALLICENCE)springer-10.1007/s00702-010-0553-x Relation of risk factors and putative premotor markers for Parkinson's disease [Elektronische Daten] [I. Liepelt-Scarfone, S. Behnke, J. Godau, K. Schweitzer, B. Wolf, A. Gaenslen, D. Berg] As both risk and premotor markers are increasingly discussed to play a key role in the pre-diagnostic phase of Parkinson's disease (PD) the aim of this study was to determine the relation between the risk factors hyperechogenicity of the substantia nigra (SN+) and/or positive family history of PD (faPD+) and putative premotor markers for PD. In a cross-sectional analysis of data of the PRIPS cohort, 1,149 volunteers older than 50years free of PD were included. In addition to the risk factors SN+ and faPD+, olfactory dysfunction was tested using the Sniffin' sticks test and motor examination was performed. History of depression and constipation was evaluated by a semi-structured interview. Of all 1,149 individuals, 880 had none of the risk markers (76.6%), 143 persons (12.4%) had SN+, 84 (7.3%) were classified as faPD+ and 42 (3.7%) persons had both risk factors. Volunteers with SN+ showed olfactory dysfunction and mild motor impairment (p≤0.001) more often. Depression was more prominent in individuals having two risk factors (p=0.05). An accumulation of premotor markers was seen in the SN+ group with or without concomitant faPD+, but not in persons with faPD+ only. The profile of premotor markers seems to differ in participants having SN+ and/or faPD+, with SN+ showing the overall highest association with most premotor markers, which implies that SN+ might be a strong indicator for a neurodegenerative process. Springer-Verlag, 2011 Transcranial ultrasound nationallicence Premotor phase nationallicence Parkinson's disease nationallicence Risk factors nationallicence Liepelt-Scarfone I. Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Hoppe-Seyler Str. 3, 72076, Tübingen, Germany aut Behnke S. Department of Neurology, University of Homburg/Saar, Homburg, Germany aut Godau J. Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Hoppe-Seyler Str. 3, 72076, Tübingen, Germany aut Schweitzer K. Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Hoppe-Seyler Str. 3, 72076, Tübingen, Germany aut Wolf B. Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Hoppe-Seyler Str. 3, 72076, Tübingen, Germany aut Gaenslen A. Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Hoppe-Seyler Str. 3, 72076, Tübingen, Germany aut Berg D. Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Hoppe-Seyler Str. 3, 72076, Tübingen, Germany aut Journal of Neural Transmission Springer Vienna 118/4(2011-04-01), 579-585 0300-9564 118:4<579 2011 118 702 https://doi.org/10.1007/s00702-010-0553-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-010-0553-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liepelt-Scarfone I. Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Hoppe-Seyler Str. 3, 72076, Tübingen, Germany aut NATIONALLICENCE 700 1- Behnke S. Department of Neurology, University of Homburg/Saar, Homburg, Germany aut NATIONALLICENCE 700 1- Godau J. Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Hoppe-Seyler Str. 3, 72076, Tübingen, Germany aut NATIONALLICENCE 700 1- Schweitzer K. Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Hoppe-Seyler Str. 3, 72076, Tübingen, Germany aut NATIONALLICENCE 700 1- Wolf B. Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Hoppe-Seyler Str. 3, 72076, Tübingen, Germany aut NATIONALLICENCE 700 1- Gaenslen A. Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Hoppe-Seyler Str. 3, 72076, Tübingen, Germany aut NATIONALLICENCE 700 1- Berg D. Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Hoppe-Seyler Str. 3, 72076, Tübingen, Germany aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/4(2011-04-01), 579-585 0300-9564 118:4<579 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer