caa a22 4500 445377127 CHVBK 20180317143006.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00702-010-0564-7 doi (NATIONALLICENCE)springer-10.1007/s00702-010-0564-7 Walter Uwe Department of Neurology, University of Rostock, Gehlsheimer Str. 20, 18147, Rostock, Germany aut Substantia nigra hyperechogenicity is a risk marker of Parkinson's disease: no [Elektronische Daten] [Uwe Walter] During the past two decades, transcranial sonography (TCS) has developed to an increasingly used brain imaging method that visualizes characteristic patterns of basal ganglia alterations in distinct movement disorders. Since the discovery of a characteristic abnormal hyperechogenic appearance of substantia nigra (SN) on TCS in Parkinson's disease (PD), which is stable during the course of the disease and probably present already in preclinical disease stages, the results of several studies have promoted the idea that this TCS finding in healthy subjects might be a risk marker of PD. The present view summarizes current scientific evidence favouring the idea that the TCS finding of SN hyperechogenicity alone may not be a (strong) risk marker of PD. Especially, it is discussed how reliable this TCS finding is, whether this TCS finding can be regarded as a progression marker or a risk marker of PD, how strongly it may indicate a risk of PD, what else if not an increased risk of PD could be indicated, and which role TCS of SN may finally play in the detection of subjects at risk of PD. Springer-Verlag, 2010 Transcranial sonography nationallicence Substantia nigra nationallicence Parkinson's disease nationallicence Risk marker nationallicence Preclinical diagnosis nationallicence Journal of Neural Transmission Springer Vienna 118/4(2011-04-01), 607-612 0300-9564 118:4<607 2011 118 702 https://doi.org/10.1007/s00702-010-0564-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-010-0564-7 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Walter Uwe Department of Neurology, University of Rostock, Gehlsheimer Str. 20, 18147, Rostock, Germany aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/4(2011-04-01), 607-612 0300-9564 118:4<607 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer