caa a22 4500 445377143 CHVBK 20180317143006.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00702-011-0613-x doi (NATIONALLICENCE)springer-10.1007/s00702-011-0613-x Doxepin concentrations in plasma and cerebrospinal fluid [Elektronische Daten] [Robert Schomburg, Daniela Remane, Klaus Fassbender, Hans Maurer, Jörg Spiegel] Doxepin—like other antidepressant drugs (ADs)—shows a variable antidepressant effect in clinical practice. The cause for this variability is as yet unclear; however, pharmacokinetic factors such as the variable permeability of doxepin into the cerebrospinal fluid (CSF), may contribute to the difference in therapeutic efficacy. We measured and correlated the concentration of doxepin and its active metabolite nordoxepin in both the plasma and CSF. Plasma and CSF samples were taken simultaneously from 21 patients who were treated with doxepin due to different clinical indications. The plasma concentration of both doxepin and nordoxepin correlated significantly with the oral dosage of doxepin (doxepin: r=+0.66, p<0.001; nordoxepin: r=+0.78, p<0.0001; Spearman's correlation). Furthermore, we found significant correlations between the plasma and CSF concentrations of both doxepin (r=+0.71; p<0.001; Pearson's correlation) and nordoxepin (r=+0.74; p<0.001). These highly significant correlations between the plasma and CSF concentrations indicate a constant CSF permeability of doxepin and its active metabolite nordoxepin. Springer-Verlag, 2011 Tricyclic antidepressants nationallicence Doxepin nationallicence Nordoxepin nationallicence Cerebrospinal fluid nationallicence Schomburg Robert Department of Neurology, University of the Saarland, Kirrberger Straße, 66421, Homburg/Saar, Germany aut Remane Daniela Institute of Clinical and Experimental Toxicology, University of the Saarland, 66421, Homburg/Saar, Germany aut Fassbender Klaus Department of Neurology, University of the Saarland, Kirrberger Straße, 66421, Homburg/Saar, Germany aut Maurer Hans Institute of Clinical and Experimental Toxicology, University of the Saarland, 66421, Homburg/Saar, Germany aut Spiegel Jörg Department of Neurology, University of the Saarland, Kirrberger Straße, 66421, Homburg/Saar, Germany aut Journal of Neural Transmission Springer Vienna 118/4(2011-04-01), 641-645 0300-9564 118:4<641 2011 118 702 https://doi.org/10.1007/s00702-011-0613-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-011-0613-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schomburg Robert Department of Neurology, University of the Saarland, Kirrberger Straße, 66421, Homburg/Saar, Germany aut NATIONALLICENCE 700 1- Remane Daniela Institute of Clinical and Experimental Toxicology, University of the Saarland, 66421, Homburg/Saar, Germany aut NATIONALLICENCE 700 1- Fassbender Klaus Department of Neurology, University of the Saarland, Kirrberger Straße, 66421, Homburg/Saar, Germany aut NATIONALLICENCE 700 1- Maurer Hans Institute of Clinical and Experimental Toxicology, University of the Saarland, 66421, Homburg/Saar, Germany aut NATIONALLICENCE 700 1- Spiegel Jörg Department of Neurology, University of the Saarland, Kirrberger Straße, 66421, Homburg/Saar, Germany aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/4(2011-04-01), 641-645 0300-9564 118:4<641 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer