caa a22 4500 445377178 CHVBK 20180317143006.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00702-010-0515-3 doi (NATIONALLICENCE)springer-10.1007/s00702-010-0515-3 Migraine is a neuronal disease [Elektronische Daten] [J. Tajti, Á. Párdutz, E. Vámos, B. Tuka, A. Kuris, Zs. Bohár, A. Fejes, J. Toldi, L. Vécsei] Migraine is a common, paroxysmal, highly disabling primary headache disorder with a genetic background. The primary cause and the origin of migraine attacks are enigmatic. Numerous clinical and experimental results suggest that activation of the trigeminal system (TS) is crucial in its pathogenesis, but the primary cause of this activation is not fully understood. Since activation of the peripheral and central arms of the TS might be related to cortical spreading depression and to the activity of distinct brainstem nuclei (e.g. the periaqueductal grey), we conclude that migraine can be explained as an altered function of the neuronal elements of the TS, the brainstem, and the cortex, the centre of this process comprising activation of the TS. In light of our findings and the literature data, therefore, we can assume that migraine is mainly a neuronal disease. Springer-Verlag, 2010 Migraine nationallicence Trigeminal system nationallicence Cortical spreading depression nationallicence Calcitonin gene-related peptide nationallicence Glutamate nationallicence Kynurenic acid nationallicence Tajti J. Department of Neurology, Albert Szent-Györgyi Clinical Centre, University of Szeged, Semmelweis U. 6, 6725, Szeged, Hungary aut Párdutz Á. Department of Neurology, Albert Szent-Györgyi Clinical Centre, University of Szeged, Semmelweis U. 6, 6725, Szeged, Hungary aut Vámos E. Department of Physiology, Anatomy and Neuroscience, Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, University of Szeged, Közép Fasor 52, 6726, Szeged, Hungary aut Tuka B. Department of Neurology, Albert Szent-Györgyi Clinical Centre, University of Szeged, Semmelweis U. 6, 6725, Szeged, Hungary aut Kuris A. Department of Neurology, Albert Szent-Györgyi Clinical Centre, University of Szeged, Semmelweis U. 6, 6725, Szeged, Hungary aut Bohár Zs Department of Neurology, Albert Szent-Györgyi Clinical Centre, University of Szeged, Semmelweis U. 6, 6725, Szeged, Hungary aut Fejes A. Department of Neurology, Albert Szent-Györgyi Clinical Centre, University of Szeged, Semmelweis U. 6, 6725, Szeged, Hungary aut Toldi J. Department of Physiology, Anatomy and Neuroscience, University of Szeged, Közép Fasor 52, 6726, Szeged, Hungary aut Vécsei L. Department of Neurology, Albert Szent-Györgyi Clinical Centre, University of Szeged, Semmelweis U. 6, 6725, Szeged, Hungary aut Journal of Neural Transmission Springer Vienna 118/4(2011-04-01), 511-524 0300-9564 118:4<511 2011 118 702 https://doi.org/10.1007/s00702-010-0515-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-010-0515-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tajti J. Department of Neurology, Albert Szent-Györgyi Clinical Centre, University of Szeged, Semmelweis U. 6, 6725, Szeged, Hungary aut NATIONALLICENCE 700 1- Párdutz Á. Department of Neurology, Albert Szent-Györgyi Clinical Centre, University of Szeged, Semmelweis U. 6, 6725, Szeged, Hungary aut NATIONALLICENCE 700 1- Vámos E. Department of Physiology, Anatomy and Neuroscience, Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, University of Szeged, Közép Fasor 52, 6726, Szeged, Hungary aut NATIONALLICENCE 700 1- Tuka B. Department of Neurology, Albert Szent-Györgyi Clinical Centre, University of Szeged, Semmelweis U. 6, 6725, Szeged, Hungary aut NATIONALLICENCE 700 1- Kuris A. Department of Neurology, Albert Szent-Györgyi Clinical Centre, University of Szeged, Semmelweis U. 6, 6725, Szeged, Hungary aut NATIONALLICENCE 700 1- Bohár Zs Department of Neurology, Albert Szent-Györgyi Clinical Centre, University of Szeged, Semmelweis U. 6, 6725, Szeged, Hungary aut NATIONALLICENCE 700 1- Fejes A. Department of Neurology, Albert Szent-Györgyi Clinical Centre, University of Szeged, Semmelweis U. 6, 6725, Szeged, Hungary aut NATIONALLICENCE 700 1- Toldi J. Department of Physiology, Anatomy and Neuroscience, University of Szeged, Közép Fasor 52, 6726, Szeged, Hungary aut NATIONALLICENCE 700 1- Vécsei L. Department of Neurology, Albert Szent-Györgyi Clinical Centre, University of Szeged, Semmelweis U. 6, 6725, Szeged, Hungary aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/4(2011-04-01), 511-524 0300-9564 118:4<511 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer