caa a22 4500 445377208 CHVBK 20180317143006.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00702-011-0674-x doi (NATIONALLICENCE)springer-10.1007/s00702-011-0674-x Rektorova Irena Applied Neurosciences Research Group, Central European Institute of Technology, CEITEC, Masaryk University, Brno, Czech Republic aut Mild cognitive impairment exists in Parkinson's disease [Elektronische Daten] [Irena Rektorova] Cognitive impairment exists in Parkinson's disease (PD) as a transitional state between cognitively intact and demented PD patients. It seems to be a risk factor for the development of dementia in PD, but the precise criteria and unfavorable cognitive profile of mild cognitive impairment in PD (MCI-PD) have not yet been established. The concept may turn to be different from that in Alzheimer's disease since we search for those already diagnosed PD patients who are at risk of developing dementia. In addition, clinical variables specific for PD also play role. Importantly, MCI possesses a metabolic basis in PD. Various biomarkers particularly including neuropsychological testing and the brain imaging hold promise in identification of MCI-PD patients with unfavorable prognoses. Well-designed longitudinal studies in MCI-PD cohorts are needed to assess the sensitivity and specificity of the PD-MCI designation as far as dementia development is concerned. Springer-Verlag, 2011 Brain imaging nationallicence Executive nationallicence Memory nationallicence Mild cognitive impairment nationallicence Parkinson's disease nationallicence Journal of Neural Transmission Springer Vienna 118/8(2011-08-01), 1179-1183 0300-9564 118:8<1179 2011 118 702 https://doi.org/10.1007/s00702-011-0674-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-011-0674-x text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Rektorova Irena Applied Neurosciences Research Group, Central European Institute of Technology, CEITEC, Masaryk University, Brno, Czech Republic aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/8(2011-08-01), 1179-1183 0300-9564 118:8<1179 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer