caa a22 4500 445377216 CHVBK 20180317143006.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00702-011-0610-0 doi (NATIONALLICENCE)springer-10.1007/s00702-011-0610-0 Naloxone decreases the inhibitory effect of somatostatin on GH release induced by cigarette smoking in man [Elektronische Daten] [Vittorio Coiro, Riccardo Volpi, Adriano Stella, Simona Cataldo, Claudio Giumelli, Francesco Maccanelli, Anna Araldi, Paolo Chiodera] To establish whether somatostatin (SRIH) exerts its inhibitory effect on the nicotine-induced release of GH by interacting with an opioid pathway, normal volunteers were treated with naloxone during (2 no-filter) cigarettes smoking and with SRIH. Nicotine significantly increased serum GH levels about 3.5 fold. Naloxone alone did not change GH rise induced by cigarette smoking. The stimulatory effect of GH by nicotine was completely blocked by SRIH. In the presence of both SRIH and naloxone, GH levels rose 1.5 fold in response to nicotine. Since naloxone only partially reversed the inhibiting action of SRIH, only a partial involvement of opioid peptides in SRIH action might be supposed. Alternatively, SRIH and naloxone-sensitive opiates might produce this inhibiting effect on GH rise in response to cigarette smoking through independent pathways. Springer-Verlag, 2011 Naloxone nationallicence Somatostatin nationallicence GH nationallicence Cigarette smoking nationallicence Coiro Vittorio Department of Internal Medicine and Biomedical Sciences, University of Parma, Via A. Gramsci 14, 43126, Parma, Italy aut Volpi Riccardo Department of Internal Medicine and Biomedical Sciences, University of Parma, Via A. Gramsci 14, 43126, Parma, Italy aut Stella Adriano Department of Internal Medicine and Biomedical Sciences, University of Parma, Via A. Gramsci 14, 43126, Parma, Italy aut Cataldo Simona Department of Internal Medicine and Biomedical Sciences, University of Parma, Via A. Gramsci 14, 43126, Parma, Italy aut Giumelli Claudio Department of Internal Medicine and Biomedical Sciences, University of Parma, Via A. Gramsci 14, 43126, Parma, Italy aut Maccanelli Francesco Department of Internal Medicine and Biomedical Sciences, University of Parma, Via A. Gramsci 14, 43126, Parma, Italy aut Araldi Anna Department of Internal Medicine and Biomedical Sciences, University of Parma, Via A. Gramsci 14, 43126, Parma, Italy aut Chiodera Paolo Department of Internal Medicine and Biomedical Sciences, University of Parma, Via A. Gramsci 14, 43126, Parma, Italy aut Journal of Neural Transmission Springer Vienna 118/8(2011-08-01), 1173-1175 0300-9564 118:8<1173 2011 118 702 https://doi.org/10.1007/s00702-011-0610-0 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-011-0610-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Coiro Vittorio Department of Internal Medicine and Biomedical Sciences, University of Parma, Via A. Gramsci 14, 43126, Parma, Italy aut NATIONALLICENCE 700 1- Volpi Riccardo Department of Internal Medicine and Biomedical Sciences, University of Parma, Via A. Gramsci 14, 43126, Parma, Italy aut NATIONALLICENCE 700 1- Stella Adriano Department of Internal Medicine and Biomedical Sciences, University of Parma, Via A. Gramsci 14, 43126, Parma, Italy aut NATIONALLICENCE 700 1- Cataldo Simona Department of Internal Medicine and Biomedical Sciences, University of Parma, Via A. Gramsci 14, 43126, Parma, Italy aut NATIONALLICENCE 700 1- Giumelli Claudio Department of Internal Medicine and Biomedical Sciences, University of Parma, Via A. Gramsci 14, 43126, Parma, Italy aut NATIONALLICENCE 700 1- Maccanelli Francesco Department of Internal Medicine and Biomedical Sciences, University of Parma, Via A. Gramsci 14, 43126, Parma, Italy aut NATIONALLICENCE 700 1- Araldi Anna Department of Internal Medicine and Biomedical Sciences, University of Parma, Via A. Gramsci 14, 43126, Parma, Italy aut NATIONALLICENCE 700 1- Chiodera Paolo Department of Internal Medicine and Biomedical Sciences, University of Parma, Via A. Gramsci 14, 43126, Parma, Italy aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/8(2011-08-01), 1173-1175 0300-9564 118:8<1173 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer