caa a22 4500 445377232 CHVBK 20180317143006.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00702-011-0581-1 doi (NATIONALLICENCE)springer-10.1007/s00702-011-0581-1 Scaling analysis of bilateral hand tremor movements in essential tremor patients [Elektronische Daten] [S. Blesic, J. Maric, N. Dragasevic, S. Milanovic, V. Kostic, Milos Ljubisavljevic] Recent evidence suggests that the dynamic-scaling behavior of the time-series of signals extracted from separate peaks of tremor spectra may reveal existence of multiple independent sources of tremor. Here, we have studied dynamic characteristics of the time-series of hand tremor movements in essential tremor (ET) patients using the detrended fluctuation analysis method. Hand accelerometry was recorded with (500g) and without weight loading under postural conditions in 25 ET patients and 20 normal subjects. The time-series comprising peak-to-peak (PtP) intervals were extracted from regions around the first three main frequency components of power spectra (PwS) of the recorded tremors. The data were compared between the load and no-load condition on dominant (related to tremor severity) and non-dominant tremor side and with the normal (physiological) oscillations in healthy subjects. Our analysis shows that, in ET, the dynamic characteristics of the main frequency component of recorded tremors exhibit scaling behavior. Furthermore, they show that the two main components of ET tremor frequency spectra, otherwise indistinguishable without load, become significantly different after inertial loading and that they differ between the tremor sides (related to tremor severity). These results show that scaling, a time-domain analysis, helps revealing tremor features previously not revealed by frequency-domain analysis and suggest that distinct oscillatory central circuits may generate the tremor in ET patients. Springer-Verlag, 2011 Tremor nationallicence Essential tremor nationallicence Fourier analysis and DFA method nationallicence Load nationallicence Tremor asymmetry nationallicence Blesic S. Laboratory for Neurophysiology, Institute for Medical Research, P.O. Box 102, 11129, Belgrade, Serbia aut Maric J. Laboratory for Neurophysiology, Institute for Medical Research, P.O. Box 102, 11129, Belgrade, Serbia aut Dragasevic N. Institute of Neurology, Clinical Center of Serbia, Medical School, University of Belgrade, Dr. Subotića 6, 11000, Belgrade, Serbia aut Milanovic S. Laboratory for Neurophysiology, Institute for Medical Research, P.O. Box 102, 11129, Belgrade, Serbia aut Kostic V. Institute of Neurology, Clinical Center of Serbia, Medical School, University of Belgrade, Dr. Subotića 6, 11000, Belgrade, Serbia aut Ljubisavljevic Milos Laboratory for Neurophysiology, Institute for Medical Research, P.O. Box 102, 11129, Belgrade, Serbia aut Journal of Neural Transmission Springer Vienna 118/8(2011-08-01), 1227-1234 0300-9564 118:8<1227 2011 118 702 https://doi.org/10.1007/s00702-011-0581-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-011-0581-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Blesic S. Laboratory for Neurophysiology, Institute for Medical Research, P.O. Box 102, 11129, Belgrade, Serbia aut NATIONALLICENCE 700 1- Maric J. Laboratory for Neurophysiology, Institute for Medical Research, P.O. Box 102, 11129, Belgrade, Serbia aut NATIONALLICENCE 700 1- Dragasevic N. Institute of Neurology, Clinical Center of Serbia, Medical School, University of Belgrade, Dr. Subotića 6, 11000, Belgrade, Serbia aut NATIONALLICENCE 700 1- Milanovic S. Laboratory for Neurophysiology, Institute for Medical Research, P.O. Box 102, 11129, Belgrade, Serbia aut NATIONALLICENCE 700 1- Kostic V. Institute of Neurology, Clinical Center of Serbia, Medical School, University of Belgrade, Dr. Subotića 6, 11000, Belgrade, Serbia aut NATIONALLICENCE 700 1- Ljubisavljevic Milos Laboratory for Neurophysiology, Institute for Medical Research, P.O. Box 102, 11129, Belgrade, Serbia aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/8(2011-08-01), 1227-1234 0300-9564 118:8<1227 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer