caa a22 4500 445377305 CHVBK 20180317143006.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00702-010-0563-8 doi (NATIONALLICENCE)springer-10.1007/s00702-010-0563-8 In vivo comparison of Richardson's syndrome and progressive supranuclear palsy-parkinsonism [Elektronische Daten] [Karin Srulijes, Grit Mallien, Sarah Bauer, Elisabeth Dietzel, Adriane Gröger, Georg Ebersbach, Daniela Berg, Walter Maetzler] Richardson's syndrome (RS) and progressive supranuclear palsy-parkinsonism (PSP-P) are the most common subtypes of PSP. Post-mortem data suggests that the clinical presentation of the two subtypes differs especially in the first 2years of disease and then converges. This hypothesis has, to our knowledge, never been confirmed in a living cohort. Medical history was used to define subtypes retrospectively in 23 consecutive PSP patients from our outpatient clinic specialized in movement disorders. 14 patients suffered from RS, and 9 from PSP-P. Using a prospective cross-sectional approach, clinical, cognitive, behavioral, speech and biochemical (cerebrospinal fluid tau levels) features were compared. RS patients showed shorter time from disease onset to diagnosis and more neuropsychological and neurobehavioral deficits than PSP-P patients, but differed not significantly with regard to clinical and biochemical features. RS and PSP-P show considerable symptoms overlap during the disease course when using routine assessments, with persisting differences regarding non-motor symptoms. Shorter disease duration of the comparably affected RS patients indicates that this subtype has an accelerated disease progression at early disease stages. Springer-Verlag, 2010 Dysarthria nationallicence Executive functions nationallicence Neuropsychology nationallicence PSP-parkinsonism nationallicence Richardson's syndrome nationallicence Srulijes Karin Department of Neurodegeneration, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, University of Tuebingen, Hoppe-Seyler-Strasse 3, 72076, Tuebingen, Germany aut Mallien Grit Movement Disorder Clinic, Beelitz-Heilstaetten, Germany aut Bauer Sarah Department of Neurodegeneration, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, University of Tuebingen, Hoppe-Seyler-Strasse 3, 72076, Tuebingen, Germany aut Dietzel Elisabeth Department of Neurodegeneration, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, University of Tuebingen, Hoppe-Seyler-Strasse 3, 72076, Tuebingen, Germany aut Gröger Adriane Department of Neurodegeneration, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, University of Tuebingen, Hoppe-Seyler-Strasse 3, 72076, Tuebingen, Germany aut Ebersbach Georg Movement Disorder Clinic, Beelitz-Heilstaetten, Germany aut Berg Daniela Department of Neurodegeneration, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, University of Tuebingen, Hoppe-Seyler-Strasse 3, 72076, Tuebingen, Germany aut Maetzler Walter Department of Neurodegeneration, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, University of Tuebingen, Hoppe-Seyler-Strasse 3, 72076, Tuebingen, Germany aut Journal of Neural Transmission Springer Vienna 118/8(2011-08-01), 1191-1197 0300-9564 118:8<1191 2011 118 702 https://doi.org/10.1007/s00702-010-0563-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-010-0563-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Srulijes Karin Department of Neurodegeneration, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, University of Tuebingen, Hoppe-Seyler-Strasse 3, 72076, Tuebingen, Germany aut NATIONALLICENCE 700 1- Mallien Grit Movement Disorder Clinic, Beelitz-Heilstaetten, Germany aut NATIONALLICENCE 700 1- Bauer Sarah Department of Neurodegeneration, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, University of Tuebingen, Hoppe-Seyler-Strasse 3, 72076, Tuebingen, Germany aut NATIONALLICENCE 700 1- Dietzel Elisabeth Department of Neurodegeneration, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, University of Tuebingen, Hoppe-Seyler-Strasse 3, 72076, Tuebingen, Germany aut NATIONALLICENCE 700 1- Gröger Adriane Department of Neurodegeneration, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, University of Tuebingen, Hoppe-Seyler-Strasse 3, 72076, Tuebingen, Germany aut NATIONALLICENCE 700 1- Ebersbach Georg Movement Disorder Clinic, Beelitz-Heilstaetten, Germany aut NATIONALLICENCE 700 1- Berg Daniela Department of Neurodegeneration, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, University of Tuebingen, Hoppe-Seyler-Strasse 3, 72076, Tuebingen, Germany aut NATIONALLICENCE 700 1- Maetzler Walter Department of Neurodegeneration, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, University of Tuebingen, Hoppe-Seyler-Strasse 3, 72076, Tuebingen, Germany aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/8(2011-08-01), 1191-1197 0300-9564 118:8<1191 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer