caa a22 4500 445377348 CHVBK 20180317143006.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00702-011-0675-9 doi (NATIONALLICENCE)springer-10.1007/s00702-011-0675-9 Is all cognitive impairment in Parkinson's disease "mild cognitive impairment”? [Elektronische Daten] [Saül Martínez-Horta, Jaime Kulisevsky] Cognitive impairment can be demonstrated in Parkinson's disease (PD) from the very beginning of the disease. Clinical manifestations range from slight deficits, only demonstrable by means of neuropsychological testing, up to dementia. If a linear involution is supposed for the cognitive worsening in PD, then the relatively subtle cognitive defects should be taken as the earliest signs of dementia implying that PD-MCI concept would be thoroughly equivalent to that used for the early prediction of other dementias among healthy population. Cognitive defects in PD, however, may not follow a normal distribution. While fronto-striatal deficits, such as working memory, set-shifting and free-recall verbal memory appear altered in most patients during long periods of time, certain functions depending on more posterior-cortical regions, such as copying or naming, usually characterize patients with dementia. Fronto-striatal and posterior-cortical cognitive defects may have a different pathophysiological substrates, evolution and prognosis. While fronto-striatal defects appear more related to dopaminergic defects, posterior-cortical defects may obey multiple neurotransmitter failure. Designing criteria to accurately diagnose PD-MCI is highly relevant for clinical treatment, research, care-giving and decision-making. Besides quantitative defects, an operative definition of MCI in PD should clearly distinguish a "risky cognitive profile” among the broad cognitive defects intrinsic to PD. Thus, along with other possible biological markers, from a neuropsychological point of view, posterior-cortical defects probably represent the very syndrome of MCI in PD. Springer-Verlag, 2011 Executive nationallicence Mild cognitive impairment nationallicence Parkinson's disease nationallicence Posterior-cortical nationallicence Martínez-Horta Saül Movement Disorders Unit, Neurology Department, Sant Pau Hospital, Universitat Autonoma de Barcelona, Sant Antoni M. Claret 167, 08025, Barcelona, Spain aut Kulisevsky Jaime Movement Disorders Unit, Neurology Department, Sant Pau Hospital, Universitat Autonoma de Barcelona, Sant Antoni M. Claret 167, 08025, Barcelona, Spain aut Journal of Neural Transmission Springer Vienna 118/8(2011-08-01), 1185-1190 0300-9564 118:8<1185 2011 118 702 https://doi.org/10.1007/s00702-011-0675-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-011-0675-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Martínez-Horta Saül Movement Disorders Unit, Neurology Department, Sant Pau Hospital, Universitat Autonoma de Barcelona, Sant Antoni M. Claret 167, 08025, Barcelona, Spain aut NATIONALLICENCE 700 1- Kulisevsky Jaime Movement Disorders Unit, Neurology Department, Sant Pau Hospital, Universitat Autonoma de Barcelona, Sant Antoni M. Claret 167, 08025, Barcelona, Spain aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/8(2011-08-01), 1185-1190 0300-9564 118:8<1185 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer