caa a22 4500 445377356 CHVBK 20180317143006.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00702-011-0623-8 doi (NATIONALLICENCE)springer-10.1007/s00702-011-0623-8 Memantine in moderate to severe Alzheimer's disease: an observational post-marketing study [Elektronische Daten] [Michael Rainer, A. Wuschitz, C. Jagsch, C. Erb, J.-J. Chirikdjian, H. Mucke] Memantine is an N-methyl-d-aspartate (NMDA) receptor antagonist, approved for the treatment of moderate to severe Alzheimer's disease (AD). We conducted a 4-month observational, post-marketing, Austrian study of memantine in 377 outpatients with moderate to severe AD. In this ‘real-life' setting, memantine was well-tolerated, and produced benefits in cognition (Mini-Mental State Examination), activities of daily living (Activities of Daily Living score), and global function (Clinical Global Impression scale). Treatment effects were apparent in both pre-treated and treatment-naïve patient subgroups. Springer-Verlag, 2011 Alzheimer's disease nationallicence Dementia nationallicence Memantine nationallicence Activities of daily living nationallicence Post-marketing nationallicence ‘Real-life' setting nationallicence Rainer Michael Memory Clinic and Psychiatric Department, Donauspital Sozialmedizinisches Zentrum Ost, Langobardenstrasse 122, 1220, Wien, Austria aut Wuschitz A. Practice for Psychiatry and Neurology, Karl Meissl Strasse 2, 1200, Wien, Austria aut Jagsch C. Psychiatric Hospital Wels, Linzer Strasse 89, 4600, Wels, Austria aut Erb C. Merz Pharmaceuticals, Eckenheimer Landstrasse 100, 60318, Frankfurt/Main, Germany aut Chirikdjian J.-J Zak Pharma GmbH, Amalienstrasse 48/8, 1130, Wien, Austria aut Mucke H. H. M. Pharma Consultancy, Enenkelstrasse 28/32, 1160, Wien, Austria aut Journal of Neural Transmission Springer Vienna 118/8(2011-08-01), 1255-1259 0300-9564 118:8<1255 2011 118 702 https://doi.org/10.1007/s00702-011-0623-8 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-011-0623-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rainer Michael Memory Clinic and Psychiatric Department, Donauspital Sozialmedizinisches Zentrum Ost, Langobardenstrasse 122, 1220, Wien, Austria aut NATIONALLICENCE 700 1- Wuschitz A. Practice for Psychiatry and Neurology, Karl Meissl Strasse 2, 1200, Wien, Austria aut NATIONALLICENCE 700 1- Jagsch C. Psychiatric Hospital Wels, Linzer Strasse 89, 4600, Wels, Austria aut NATIONALLICENCE 700 1- Erb C. Merz Pharmaceuticals, Eckenheimer Landstrasse 100, 60318, Frankfurt/Main, Germany aut NATIONALLICENCE 700 1- Chirikdjian J.-J Zak Pharma GmbH, Amalienstrasse 48/8, 1130, Wien, Austria aut NATIONALLICENCE 700 1- Mucke H. H. M. Pharma Consultancy, Enenkelstrasse 28/32, 1160, Wien, Austria aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/8(2011-08-01), 1255-1259 0300-9564 118:8<1255 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer