caa a22 4500 445377372 CHVBK 20180317143007.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00702-011-0648-z doi (NATIONALLICENCE)springer-10.1007/s00702-011-0648-z Chromogranin peptides in brain diseases [Elektronische Daten] [Michael Willis, Irmgard Leitner, Kurt Jellinger, Josef Marksteiner] Synaptic disturbances may play a key role in the pathophysiology of neuropsychiatric diseases. In this article, we review immunohistological findings of chromogranin peptides in neurodegenerative and neurodevelopmental disorders, with particular emphasis on Alzheimer's disease, the disorder chromogranins have been studied most extensively. Data was collected from existing and new experimental data and medline research. This review focuses on synaptic changes elicited by chromogranin peptides immunoreactivity in Alzheimer's disease, as well in schizophrenia and amyotrophic lateral sclerosis (ALS). An imbalanced availability of chromogranin peptides may be responsible for impaired neurotransmission and a reduced functioning of dense core vesicles. Since chromogranin A was postulated as a potent proinflammatory agent, we focused on chromogranin A in neuroinflammation in Alzheimer's disease and ALS. Further understanding of role and function of chromogranin peptides in neuropathological conditions is still required. Springer-Verlag, 2011 Chromogranin A nationallicence Chromogranin B nationallicence Secretogranin II nationallicence Secretoneurin nationallicence Alzheimer's disease nationallicence Aβ : Amyloid-β nationallicence AβPP : Amyloid-β precursor protein nationallicence ALS : Amyotrophic lateral sclerosis nationallicence AD : Alzheimer's disease nationallicence BACE1 : Beta-secretase 1 nationallicence CA : Cornu ammonis nationallicence CgA : Chromogranin A nationallicence CgB : Chromogranin B nationallicence Cgs : Chromogranins nationallicence CSF : Cerebrospinal fluid nationallicence DAB : 3,3′-diaminobenzidine nationallicence GFAP : Glial fibrillary acidic protein nationallicence IP3 : Inositol-1,4,5-trisphosphate nationallicence LDCV : Large dense core vesicles nationallicence -LI : Like immunoreactivity nationallicence NMDA : N-Methyl-d-aspartate nationallicence PFC : Prefrontal cortex nationallicence PCP : Phencyclidin nationallicence SgII : Secretogranin II nationallicence SN : Secretoneurin nationallicence SNPs : Single nucleotide polymorphisms nationallicence SOD1 : Superoxide dismutase 1 nationallicence SR : Scavenger receptors nationallicence SSV : Small synaptic vesicles nationallicence Willis Michael Department of General Psychiatry, Medical University Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria aut Leitner Irmgard Division of Molecular and Cellular Pharmacology, Medical University Innsbruck, Peter Mayr Strasse 1, 6020, Innsbruck, Austria aut Jellinger Kurt Institute of Clinical Neurobiology, Kenyongasse 18, 1070, Vienna, Austria aut Marksteiner Josef Department of Psychiatry and Psychotherapy, LKH Hall, Milserstrasse 10, 6060, Hall, Austria aut Journal of Neural Transmission Springer Vienna 118/5(2011-05-01), 727-735 0300-9564 118:5<727 2011 118 702 https://doi.org/10.1007/s00702-011-0648-z text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-011-0648-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Willis Michael Department of General Psychiatry, Medical University Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria aut NATIONALLICENCE 700 1- Leitner Irmgard Division of Molecular and Cellular Pharmacology, Medical University Innsbruck, Peter Mayr Strasse 1, 6020, Innsbruck, Austria aut NATIONALLICENCE 700 1- Jellinger Kurt Institute of Clinical Neurobiology, Kenyongasse 18, 1070, Vienna, Austria aut NATIONALLICENCE 700 1- Marksteiner Josef Department of Psychiatry and Psychotherapy, LKH Hall, Milserstrasse 10, 6060, Hall, Austria aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/5(2011-05-01), 727-735 0300-9564 118:5<727 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer