caa a22 4500 445377380 CHVBK 20180317143007.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00702-011-0651-4 doi (NATIONALLICENCE)springer-10.1007/s00702-011-0651-4 Cerebral amyloid angiopathy in streptozotocin rat model of sporadic Alzheimer's disease: a long-term follow up study [Elektronische Daten] [Melita Salkovic-Petrisic, Jelena Osmanovic-Barilar, Martina Brückner, Siegfried Hoyer, Thomas Arendt, Peter Riederer] Cerebral amyloid angiopathy is manifested as accumulation of amyloid β (Aβ) peptide in the wall of meningeal and cerebral arteries, arterioles and capillaries and is frequently found postmortem in sporadic Alzheimer's disease (sAD) patients. It is difficult to assess when and how cerebral amyloid angiopathy develops and progresses in humans in vivo, which is why animal AD models are used. Streptozotocin-intracerebroventricularly (STZ-icv) treated rats have been recently proposed as the model of sAD which develops insulin resistant brain state preceding Aβ pathology development. Vascular Aβ deposits in the brain of STZ-icv-treated rats (3months old at the time of icv treatment) were visualized by Thioflavine-S staining, Congo red staining and Aβ immunohistochemistry. Thioflavine-S and Congo red staining revealed diffuse congophilic deposits in the wall of meningeal and cortical blood vessels both 6 and 9months after the STZ-icv treatment. Preliminary Aβ1-42 and Aβ1-16 immunohistochemistry experiments showed positive staining in blood vessels 3 and 9months after the STZ-icv treatment, respectively. Results suggest that cerebral amyloid angiopathy observed 6 and 9months after the STZ-icv treatment seems to be a continuation and progression of the amyloid pathology observed already 3months following the STZ-icv treatment in this non-transgenic sAD animal model. Springer-Verlag, 2011 Streptozotocin nationallicence Intracerebroventricular nationallicence Cerebral amyloid angiopathy nationallicence Amyloid β nationallicence Salkovic-Petrisic Melita Department of Pharmacology and Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Salata 11, HR 10 000, Zagreb, Croatia aut Osmanovic-Barilar Jelena Department of Pharmacology and Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Salata 11, HR 10 000, Zagreb, Croatia aut Brückner Martina Department of Molecular and Cellular Mechanisms of Neurodegeneration, Paul Flechsig Institute for Brain Research, University Leipzig, Jahnallee 59, 04109, Leipzig, Germany aut Hoyer Siegfried Department of Pathology, University Clinic, University of Heidelberg, Im Neuenheimer Feld 220/221, 69120, Heidelberg, Germany aut Arendt Thomas Department of Molecular and Cellular Mechanisms of Neurodegeneration, Paul Flechsig Institute for Brain Research, University Leipzig, Jahnallee 59, 04109, Leipzig, Germany aut Riederer Peter Clinic and Policlinic of Psychiatry, Psychosomatic and Psychotherapy Department, Clinical Neurochemistry, University of Wuerzburg, Fuechsleinstr. 15, 97080, Wuerzburg, Germany aut Journal of Neural Transmission Springer Vienna 118/5(2011-05-01), 765-772 0300-9564 118:5<765 2011 118 702 https://doi.org/10.1007/s00702-011-0651-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-011-0651-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Salkovic-Petrisic Melita Department of Pharmacology and Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Salata 11, HR 10 000, Zagreb, Croatia aut NATIONALLICENCE 700 1- Osmanovic-Barilar Jelena Department of Pharmacology and Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Salata 11, HR 10 000, Zagreb, Croatia aut NATIONALLICENCE 700 1- Brückner Martina Department of Molecular and Cellular Mechanisms of Neurodegeneration, Paul Flechsig Institute for Brain Research, University Leipzig, Jahnallee 59, 04109, Leipzig, Germany aut NATIONALLICENCE 700 1- Hoyer Siegfried Department of Pathology, University Clinic, University of Heidelberg, Im Neuenheimer Feld 220/221, 69120, Heidelberg, Germany aut NATIONALLICENCE 700 1- Arendt Thomas Department of Molecular and Cellular Mechanisms of Neurodegeneration, Paul Flechsig Institute for Brain Research, University Leipzig, Jahnallee 59, 04109, Leipzig, Germany aut NATIONALLICENCE 700 1- Riederer Peter Clinic and Policlinic of Psychiatry, Psychosomatic and Psychotherapy Department, Clinical Neurochemistry, University of Wuerzburg, Fuechsleinstr. 15, 97080, Wuerzburg, Germany aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/5(2011-05-01), 765-772 0300-9564 118:5<765 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer