caa a22 4500 445377402 CHVBK 20180317143007.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00702-011-0594-9 doi (NATIONALLICENCE)springer-10.1007/s00702-011-0594-9 MRI-detected white matter lesions: do they really matter? [Elektronische Daten] [Reinhold Schmidt, Anja Grazer, Christian Enzinger, Stefan Ropele, Nina Homayoon, Aga Pluta-Fuerst, Petra Schwingenschuh, Petra Katschnig, Margherita Cavalieri, Helena Schmidt, Christian Langkammer, Franz Ebner, Franz Fazekas] Despite extensive research over the last decades the clinical significance of white matter lesions (WMLs) is still a matter of debate. Here, we review current knowledge of the correlation between WMLs and cognitive functioning as well as their predictive value for future stroke, dementia, and functional decline in activities of daily living. There is clear evidence that age-related WMLs relate to all of these outcomes on a group level, but the inter-individual variability is high. The association between WMLs and clinical phenotypes exists particularly for early confluent to confluent changes, which are ischaemic in aetiology and progress quickly over time. One reason for the variability of the relationship between WMLs and clinic on an individual level is probably the complexity of the association. Numerous factors such as cognitive reserve, concomitant loss of brain volume, and ultrastructural changes have been identified as mediators between white matter damage and clinical findings, and need to be incorporated in the consideration of WMLs as visible markers of these detrimental processes. Springer-Verlag, 2011 Magnetic resonance imaging nationallicence MRI nationallicence White matter lesions nationallicence Cognition nationallicence Dementia nationallicence AD : Alzheimer's disease nationallicence ADAS : Alzheimer's disease assessment scale nationallicence ARIC : Atherosclerosis risk in communities nationallicence DM II : Diabetes mellitus type 2 nationallicence CDR : Clinical dementia rating (scale) nationallicence CASCADE : Cardiovascular determinants of dementia (study) nationallicence LADIS : Leukoaraiosis and disability (study) nationallicence MCI : Mild cognitive impairment nationallicence MEMO : Memory and morbidity in Augsburg elderly (study) nationallicence MMSE : Mini mental state examination nationallicence MRI : Magnetic resonance imaging nationallicence PROSPER : Prospective study of Pravastatin in the elderly at risk nationallicence SMART-MR : Second manifestations of ARTerial disease-MR substudy nationallicence WMH : White matter hyperintensities nationallicence WML : White matter lesions nationallicence Schmidt Reinhold Division of Special Neurology, Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036, Graz, Austria aut Grazer Anja Division of Special Neurology, Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036, Graz, Austria aut Enzinger Christian Division of General Neurology, Department of Neurology, Medical University of Graz, Graz, Austria aut Ropele Stefan Division of General Neurology, Department of Neurology, Medical University of Graz, Graz, Austria aut Homayoon Nina Division of Special Neurology, Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036, Graz, Austria aut Pluta-Fuerst Aga Division of General Neurology, Department of Neurology, Medical University of Graz, Graz, Austria aut Schwingenschuh Petra Division of Special Neurology, Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036, Graz, Austria aut Katschnig Petra Division of Special Neurology, Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036, Graz, Austria aut Cavalieri Margherita Division of Special Neurology, Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036, Graz, Austria aut Schmidt Helena Division of General Neurology, Department of Neurology, Medical University of Graz, Graz, Austria aut Langkammer Christian Division of General Neurology, Department of Neurology, Medical University of Graz, Graz, Austria aut Ebner Franz Division of Neuroradiology, Department of Radiology, Medical University of Graz, Graz, Austria aut Fazekas Franz Division of General Neurology, Department of Neurology, Medical University of Graz, Graz, Austria aut Journal of Neural Transmission Springer Vienna 118/5(2011-05-01), 673-681 0300-9564 118:5<673 2011 118 702 https://doi.org/10.1007/s00702-011-0594-9 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-011-0594-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schmidt Reinhold Division of Special Neurology, Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036, Graz, Austria aut NATIONALLICENCE 700 1- Grazer Anja Division of Special Neurology, Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036, Graz, Austria aut NATIONALLICENCE 700 1- Enzinger Christian Division of General Neurology, Department of Neurology, Medical University of Graz, Graz, Austria aut NATIONALLICENCE 700 1- Ropele Stefan Division of General Neurology, Department of Neurology, Medical University of Graz, Graz, Austria aut NATIONALLICENCE 700 1- Homayoon Nina Division of Special Neurology, Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036, Graz, Austria aut NATIONALLICENCE 700 1- Pluta-Fuerst Aga Division of General Neurology, Department of Neurology, Medical University of Graz, Graz, Austria aut NATIONALLICENCE 700 1- Schwingenschuh Petra Division of Special Neurology, Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036, Graz, Austria aut NATIONALLICENCE 700 1- Katschnig Petra Division of Special Neurology, Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036, Graz, Austria aut NATIONALLICENCE 700 1- Cavalieri Margherita Division of Special Neurology, Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036, Graz, Austria aut NATIONALLICENCE 700 1- Schmidt Helena Division of General Neurology, Department of Neurology, Medical University of Graz, Graz, Austria aut NATIONALLICENCE 700 1- Langkammer Christian Division of General Neurology, Department of Neurology, Medical University of Graz, Graz, Austria aut NATIONALLICENCE 700 1- Ebner Franz Division of Neuroradiology, Department of Radiology, Medical University of Graz, Graz, Austria aut NATIONALLICENCE 700 1- Fazekas Franz Division of General Neurology, Department of Neurology, Medical University of Graz, Graz, Austria aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/5(2011-05-01), 673-681 0300-9564 118:5<673 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer