caa a22 4500 445377461 CHVBK 20180317143007.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00702-010-0574-5 doi (NATIONALLICENCE)springer-10.1007/s00702-010-0574-5 TAR-DNA binding protein-43 and alterations in the hippocampus [Elektronische Daten] [Tuomas Rauramaa, Maria Pikkarainen, Elisabet Englund, Paul Ince, Kurt Jellinger, Anders Paetau, Irina Alafuzoff] Immunocytochemistry for transactive response binding protein-43 (TDP43) was assessed in the granular cell layer of the dentate gyrus in 250 cases displaying hippocampal pathology identified by haematoxylin-eosin staining. 18%, nearly one in five displayed TDP43 immunoreactive pathology in the granular cell layer of hippocampus. This percentage increased to 43% when only subjects with hippocampal pathology other than vascular in origin were included. When only subjects with severe Alzheimer's disease-related pathology were included, 42% displayed TDP43-immunoreactive pathology, increasing to 60% when concomitant Alzheimer's disease and α-synuclein pathology were present. Within this setting, TDP43-immunoreactive pathology was observed to be present in 6% of subjects with hippocampal pathology but without any cognitive impairment. Our findings justify assessment of TDP43 pathology in every case where a pathological alteration is observed in the hippocampus using a routine stain. Springer-Verlag, 2011 TAR-DNA binding protein-43 nationallicence Hyperphosphorylated-τ nationallicence p62 nationallicence Immunohistochemistry nationallicence Post-mortem nationallicence Hippocampal alterations nationallicence Rauramaa Tuomas Department of Pathology, Kuopio University Hospital, Kuopio, Finland aut Pikkarainen Maria Institute of Clinical Medicine, Unit of Neurology, Section of Neuropathology, University of Eastern Finland, Kuopio, Finland aut Englund Elisabet Department of Pathology, University Hospital, Lund, Sweden aut Ince Paul Department of Neurosciences, University of Sheffield, Sheffield, UK aut Jellinger Kurt Institute of Clinical Neurobiology, Vienna, Austria aut Paetau Anders Department of Pathology, University of Helsinki, Helsinki, Finland aut Alafuzoff Irina Department of Pathology, Kuopio University Hospital, Kuopio, Finland aut Journal of Neural Transmission Springer Vienna 118/5(2011-05-01), 683-689 0300-9564 118:5<683 2011 118 702 https://doi.org/10.1007/s00702-010-0574-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-010-0574-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rauramaa Tuomas Department of Pathology, Kuopio University Hospital, Kuopio, Finland aut NATIONALLICENCE 700 1- Pikkarainen Maria Institute of Clinical Medicine, Unit of Neurology, Section of Neuropathology, University of Eastern Finland, Kuopio, Finland aut NATIONALLICENCE 700 1- Englund Elisabet Department of Pathology, University Hospital, Lund, Sweden aut NATIONALLICENCE 700 1- Ince Paul Department of Neurosciences, University of Sheffield, Sheffield, UK aut NATIONALLICENCE 700 1- Jellinger Kurt Institute of Clinical Neurobiology, Vienna, Austria aut NATIONALLICENCE 700 1- Paetau Anders Department of Pathology, University of Helsinki, Helsinki, Finland aut NATIONALLICENCE 700 1- Alafuzoff Irina Department of Pathology, Kuopio University Hospital, Kuopio, Finland aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/5(2011-05-01), 683-689 0300-9564 118:5<683 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer