caa a22 4500 44537747X CHVBK 20180317143007.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00702-010-0576-3 doi (NATIONALLICENCE)springer-10.1007/s00702-010-0576-3 Modelling progressive autonomic failure in MSA: where are we now? [Elektronische Daten] [Sylvia Stemberger, Gregor Wenning] Multiple system atrophy (MSA) is a fatal late-onset α-synucleinopathy that presents with features of ataxia, Parkinsonism, and pyramidal dysfunction in any combination. Over the last decade, efforts have been made to develop preclinical MSA testbeds for novel interventional strategies. The main focus has been on murine analogues of MSA-linked motor features and their underlying brainstem, cerebellar and basal ganglia pathology. Although progressive autonomic failure (AF) is a prominent clinical feature of patients with MSA, reflecting a disruption of both central and peripheral autonomic networks controlling cardiovascular, respiratory, urogenital, gastrointestinal and sudomotor functions, attempts of modelling this aspect of the human disease have been limited. However, emerging evidence suggests that AF-like features may occur in transgenic MSA models reflecting α-synucleinopathy lesions in distributed autonomic networks. Further research is needed to fully characterize both autonomic and motor features in optimized preclinical MSA models. Springer-Verlag, 2011 Multiple system atrophy nationallicence Autonomic failure nationallicence α-synuclein nationallicence Brainstem nationallicence Stemberger Sylvia Division of Clinical Neurobiology, Department of Neurology, Innsbruck Medical University, Anichstr. 35, 6020, Innsbruck, Austria aut Wenning Gregor Division of Clinical Neurobiology, Department of Neurology, Innsbruck Medical University, Anichstr. 35, 6020, Innsbruck, Austria aut Journal of Neural Transmission Springer Vienna 118/5(2011-05-01), 841-847 0300-9564 118:5<841 2011 118 702 https://doi.org/10.1007/s00702-010-0576-3 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-010-0576-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Stemberger Sylvia Division of Clinical Neurobiology, Department of Neurology, Innsbruck Medical University, Anichstr. 35, 6020, Innsbruck, Austria aut NATIONALLICENCE 700 1- Wenning Gregor Division of Clinical Neurobiology, Department of Neurology, Innsbruck Medical University, Anichstr. 35, 6020, Innsbruck, Austria aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/5(2011-05-01), 841-847 0300-9564 118:5<841 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer