caa a22 4500 445377496 CHVBK 20180317143007.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00702-011-0617-6 doi (NATIONALLICENCE)springer-10.1007/s00702-011-0617-6 A proteomics study reveals a predominant change in MaoB expression in platelets of healthy volunteers after high protein meat diet: relationship to the methylation cycle [Elektronische Daten] [Maria Zellner, Rita Babeluk, Lene Jakobsen, Christopher Gerner, Ellen Umlauf, Ivo Volf, Erich Roth, Jens Kondrup] Studies investigating the impact of high meat intake on cognition have yielded contradictory results as some show improved cognitive performance, whereas others report an increase of risk factors for dementia. However, few studies were designed to directly assess the effect of a high protein (HP) diet on both cognitive performance and corresponding biochemical parameters. A randomised intervention study was conducted with 23 healthy males (aged 19-31years) to investigate the effects of a usual (UP) versus a HP diet on cognitive function and on the platelet proteome a well-established model for neurons. The study individuals were assigned to either a UP diet (15% energy) or a HP diet (30% energy) for 3weeks with controlled intake of food and beverages. Blood samples were taken along with measurements of cognitive functions at the beginning and at the end of the intervention period. Among 908 reproducibly studied platelet proteins only the level of monoamine oxidase B (MaoB), a neurotransmitter degrading enzyme, decreased by 26% significantly (adjusted P value<0.05) due to the HP diet. In addition, we found a correlation (r=0.477; P<0.02) between the decrease of MaoB expression and the shortened reaction time (cognitive function) which is in accordance with reports that dementia patients show increased MaoB activity. Plasma vitamin B12 concentration was increased by the HP diet and correlates inversely with platelet MaoB expression (r=−0.35; P<0.02). Healthy young males on a HP diet showed improved cognitive function and counteract well-known dementia biomarkers such as platelet MaoB and components of the methylation cycle such as vitamin B12 and homocysteine. Springer-Verlag, 2011 High protein diet nationallicence Platelet proteomics nationallicence Cognition nationallicence MaoB nationallicence Dementia nationallicence Alzheimer's disease nationallicence Zellner Maria Surgical Research Laboratories, Medical University of Vienna, Vienna, Austria aut Babeluk Rita Surgical Research Laboratories, Medical University of Vienna, Vienna, Austria aut Jakobsen Lene Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark aut Gerner Christopher Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, Vienna, Austria aut Umlauf Ellen Institute of Physiology, Medical University of Vienna, Schwarzspanierstrasse 17, 1090, Vienna, Austria aut Volf Ivo Institute of Physiology, Medical University of Vienna, Schwarzspanierstrasse 17, 1090, Vienna, Austria aut Roth Erich Surgical Research Laboratories, Medical University of Vienna, Vienna, Austria aut Kondrup Jens Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark aut Journal of Neural Transmission Springer Vienna 118/5(2011-05-01), 653-662 0300-9564 118:5<653 2011 118 702 https://doi.org/10.1007/s00702-011-0617-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-011-0617-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zellner Maria Surgical Research Laboratories, Medical University of Vienna, Vienna, Austria aut NATIONALLICENCE 700 1- Babeluk Rita Surgical Research Laboratories, Medical University of Vienna, Vienna, Austria aut NATIONALLICENCE 700 1- Jakobsen Lene Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Gerner Christopher Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, Vienna, Austria aut NATIONALLICENCE 700 1- Umlauf Ellen Institute of Physiology, Medical University of Vienna, Schwarzspanierstrasse 17, 1090, Vienna, Austria aut NATIONALLICENCE 700 1- Volf Ivo Institute of Physiology, Medical University of Vienna, Schwarzspanierstrasse 17, 1090, Vienna, Austria aut NATIONALLICENCE 700 1- Roth Erich Surgical Research Laboratories, Medical University of Vienna, Vienna, Austria aut NATIONALLICENCE 700 1- Kondrup Jens Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/5(2011-05-01), 653-662 0300-9564 118:5<653 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer