caa a22 4500 44537750X CHVBK 20180317143007.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00702-011-0599-4 doi (NATIONALLICENCE)springer-10.1007/s00702-011-0599-4 Prospective study on association between plasma amyloid beta-42 and atherosclerotic risk factors [Elektronische Daten] [Imrich Blasko, Georg Kemmler, Susanne Jungwirth, Ildiko Wichart, Silvia Weissgram, Kurt Jellinger, Karl Tragl, Peter Fischer] An association between plasma Amyloid beta peptides (Aβ) with blood lipids was reported in cross-sectional studies. The present study examined the 5-year prospective association of atherosclerotic risk factors with plasma Aβ42 in 440 elderly persons without both Alzheimer's disease (AD) or mild cognitive impairment (MCI) at baseline. Persons in the highest tertile of total cholesterol (TC) or LDL-C at baseline showed low plasma Aβ42 at 5years. Regression analysis confirmed TC and LDL-C as negative predictors of Aβ42 (p=0.001). An increase over 5years of HDL-C was a negative predictor and the presence of an APOE ε4 allele was a positive predictor for decrease of Aβ42 in converters to MCI. In converters to AD, increase of both TC and of HbA1c were positive predictors of Aβ42 levels at 5years. Analysis of covariance showed a positive association between Δ-TC, Δ-LDL-C, Δ-HbA1c, and levels of Aβ42 at 5years (p=0.006; 0.013 and 0.027 resp.) in converters to AD independently on lipid-lowering treatment. The association of vascular risk factors TC, LDL-C, and HbA1c with higher Aβ42 levels might, after confirmation in other cohorts, influence the development of lifestyle interventions concerning plasma Aβ42 and AD. Springer-Verlag, 2011 Plasma Aβ42 nationallicence Total cholesterol nationallicence LDL-cholesterol nationallicence HDL-cholesterol nationallicence Change over time nationallicence Body mass index nationallicence Blasko Imrich Section of Psychiatry and Psychotherapy, Department of General and Social Psychiatry, Innsbruck Medical University, Anichstrasse 35, 6020, Innsbruck, Austria aut Kemmler Georg Section of Psychiatry and Psychotherapy, Department of General and Social Psychiatry, Innsbruck Medical University, Anichstrasse 35, 6020, Innsbruck, Austria aut Jungwirth Susanne Ludwig Boltzmann Society, L. Boltzmann Institute of Aging Research, Vienna, Austria aut Wichart Ildiko Institute of Clinical Neurobiology, Vienna, Austria aut Weissgram Silvia Ludwig Boltzmann Society, L. Boltzmann Institute of Aging Research, Vienna, Austria aut Jellinger Kurt Institute of Clinical Neurobiology, Vienna, Austria aut Tragl Karl Ludwig Boltzmann Society, L. Boltzmann Institute of Aging Research, Vienna, Austria aut Fischer Peter Ludwig Boltzmann Society, L. Boltzmann Institute of Aging Research, Vienna, Austria aut Journal of Neural Transmission Springer Vienna 118/5(2011-05-01), 663-672 0300-9564 118:5<663 2011 118 702 https://doi.org/10.1007/s00702-011-0599-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-011-0599-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Blasko Imrich Section of Psychiatry and Psychotherapy, Department of General and Social Psychiatry, Innsbruck Medical University, Anichstrasse 35, 6020, Innsbruck, Austria aut NATIONALLICENCE 700 1- Kemmler Georg Section of Psychiatry and Psychotherapy, Department of General and Social Psychiatry, Innsbruck Medical University, Anichstrasse 35, 6020, Innsbruck, Austria aut NATIONALLICENCE 700 1- Jungwirth Susanne Ludwig Boltzmann Society, L. Boltzmann Institute of Aging Research, Vienna, Austria aut NATIONALLICENCE 700 1- Wichart Ildiko Institute of Clinical Neurobiology, Vienna, Austria aut NATIONALLICENCE 700 1- Weissgram Silvia Ludwig Boltzmann Society, L. Boltzmann Institute of Aging Research, Vienna, Austria aut NATIONALLICENCE 700 1- Jellinger Kurt Institute of Clinical Neurobiology, Vienna, Austria aut NATIONALLICENCE 700 1- Tragl Karl Ludwig Boltzmann Society, L. Boltzmann Institute of Aging Research, Vienna, Austria aut NATIONALLICENCE 700 1- Fischer Peter Ludwig Boltzmann Society, L. Boltzmann Institute of Aging Research, Vienna, Austria aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/5(2011-05-01), 663-672 0300-9564 118:5<663 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer