caa a22 4500 445377526 CHVBK 20180317143007.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00702-011-0621-x doi (NATIONALLICENCE)springer-10.1007/s00702-011-0621-x Altered functional organization of the motor system related to ankle movements in Parkinson's disease: insights from functional MRI [Elektronische Daten] [Petra Katschnig, Petra Schwingenschuh, Margit Jehna, Martin Švehlík, Katja Petrovic, Stefan Ropele, Ernst Zwick, Erwin Ott, Franz Fazekas, Reinhold Schmidt, Christian Enzinger] Bradykinesia represents one of the cardinal and most incapacitating features of Parkinson's disease (PD). In this context, investigating the cerebral control mechanisms for limb movements and defining the associated functional neuroanatomy is important for understanding the impaired motor activity in PD. So far, most studies have focused on motor control of upper limb movements in PD. Ankle movement functional MRI (fMRI) paradigms have been used to non-invasively investigate supraspinal control mechanisms relevant for lower limb movements in healthy subjects, patients with Multiple sclerosis, and stroke. Using such an active and passive paradigm in 20 PD patients off medication (mean age 66.8±7.2years) and 20 healthy controls (HC; mean age 62.3±6.9years), we here wished to probe for possible activation differences between PD and HC and define functional correlates of lower limb function in PD. Active ankle movement versus rest was associated with a robust activation pattern in expected somatotopy involving key motor areas both in PD and HC. However, contrasting activation patterns in patients versus controls revealed excess activation in the patients in frontal regions comprising pre-supplementary motor areas (pre-SMA) and SMA proper. The extent of SMA activation did not correlate with behavioural parameters related to gait or motor function, and no differences were seen with the passive paradigm. This finding might be indicative of higher demand and increased effort in PD patients to ensure adequate motor function despite existing deficits. The missing correlation with behavioural variables and lack of differences with the passive paradigm suggests that this excess activation is not exclusively compensatory and also not hard-wired. Springer-Verlag, 2011 Gait dysfunction nationallicence Parkinson's disease nationallicence fMRI nationallicence SMA proper nationallicence Pre-SMA nationallicence Katschnig Petra Department of Neurology, Division of Special Neurology, Medical University of Graz, Graz, Austria aut Schwingenschuh Petra Department of Neurology, Division of Special Neurology, Medical University of Graz, Graz, Austria aut Jehna Margit Department of Neurology, Division of Special Neurology, Medical University of Graz, Graz, Austria aut Švehlík Martin Department of Paediatric Orthopaedics and Paediatric Surgery, Medical University of Graz, Graz, Austria aut Petrovic Katja Department of Neurology, Division of General Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036, Graz, Austria aut Ropele Stefan Department of Neurology, Division of General Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036, Graz, Austria aut Zwick Ernst Department of Paediatric Orthopaedics and Paediatric Surgery, Medical University of Graz, Graz, Austria aut Ott Erwin Department of Neurology, Division of Special Neurology, Medical University of Graz, Graz, Austria aut Fazekas Franz Department of Neurology, Division of General Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036, Graz, Austria aut Schmidt Reinhold Department of Neurology, Division of Special Neurology, Medical University of Graz, Graz, Austria aut Enzinger Christian Department of Neurology, Division of General Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036, Graz, Austria aut Journal of Neural Transmission Springer Vienna 118/5(2011-05-01), 783-793 0300-9564 118:5<783 2011 118 702 https://doi.org/10.1007/s00702-011-0621-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-011-0621-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Katschnig Petra Department of Neurology, Division of Special Neurology, Medical University of Graz, Graz, Austria aut NATIONALLICENCE 700 1- Schwingenschuh Petra Department of Neurology, Division of Special Neurology, Medical University of Graz, Graz, Austria aut NATIONALLICENCE 700 1- Jehna Margit Department of Neurology, Division of Special Neurology, Medical University of Graz, Graz, Austria aut NATIONALLICENCE 700 1- Švehlík Martin Department of Paediatric Orthopaedics and Paediatric Surgery, Medical University of Graz, Graz, Austria aut NATIONALLICENCE 700 1- Petrovic Katja Department of Neurology, Division of General Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036, Graz, Austria aut NATIONALLICENCE 700 1- Ropele Stefan Department of Neurology, Division of General Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036, Graz, Austria aut NATIONALLICENCE 700 1- Zwick Ernst Department of Paediatric Orthopaedics and Paediatric Surgery, Medical University of Graz, Graz, Austria aut NATIONALLICENCE 700 1- Ott Erwin Department of Neurology, Division of Special Neurology, Medical University of Graz, Graz, Austria aut NATIONALLICENCE 700 1- Fazekas Franz Department of Neurology, Division of General Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036, Graz, Austria aut NATIONALLICENCE 700 1- Schmidt Reinhold Department of Neurology, Division of Special Neurology, Medical University of Graz, Graz, Austria aut NATIONALLICENCE 700 1- Enzinger Christian Department of Neurology, Division of General Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036, Graz, Austria aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/5(2011-05-01), 783-793 0300-9564 118:5<783 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer