caa a22 4500 445377542 CHVBK 20180317143007.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00702-011-0607-8 doi (NATIONALLICENCE)springer-10.1007/s00702-011-0607-8 Lassmann Hans Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090, Wien, Austria aut Mechanisms of neurodegeneration shared between multiple sclerosis and Alzheimer's disease [Elektronische Daten] [Hans Lassmann] Multiple sclerosis and Alzheimer's disease are fundamentally different diseases. However, recent data suggest that certain mechanisms of neurodegeneration may be shared between the two diseases. Inflammation drives the disease in multiple sclerosis. It is also present in Alzheimer's disease lesions, where it may have dual functions in amyloid clearance as well as in the propagation of neurodegeneration. In both diseases, degeneration of neurons, axons, and synapses occur on the background of profound mitochondrial injury. Reactive oxygen and nitric oxide intermediates are major candidates for the induction of mitochondrial injury. Radicals are produced through the induction of the respiratory burst in activated microglia, which are present in the lesions of both diseases. In addition, liberation of toxic iron from intracellular stores may augment radical formation. Finally reactive oxygen species are also produced in the course of mitochondrial injury itself. Anti-oxidant and mitochondria protective therapeutic strategies may be beneficial both in multiple sclerosis and Alzheimer's disease in particular in early stages of the disease. Springer-Verlag, 2011 Multiple sclerosis nationallicence Alzheimer's disease nationallicence Inflammation nationallicence Mitochondria nationallicence Oxidative damage nationallicence Journal of Neural Transmission Springer Vienna 118/5(2011-05-01), 747-752 0300-9564 118:5<747 2011 118 702 https://doi.org/10.1007/s00702-011-0607-8 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-011-0607-8 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Lassmann Hans Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090, Wien, Austria aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/5(2011-05-01), 747-752 0300-9564 118:5<747 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer