caa a22 4500 445377550 CHVBK 20180317143007.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00702-011-0641-6 doi (NATIONALLICENCE)springer-10.1007/s00702-011-0641-6 Striatal β-amyloid in dementia with Lewy bodies but not Parkinson's disease [Elektronische Daten] [Glenda Halliday, Yun Song, Antony Harding] Professor Jellinger first identified that striatal Aβ deposition at postmortem seemed to differentiate cases of dementia with Lewy bodies (DLB) from those with Parkinson's disease dementia (PDD), a finding subsequently questioned. Our replication study in 34 prospectively studied cases assessed the ability of striatal Aβ deposition to differentiate DLB from PDD, and also assessed the relationship between striatal and cortical Aβ deposition and α-synuclein-immunoreactive pathologies, using previously published protocols. Cases with DLB had significantly shorter durations and greater dementia severities compared with cases with PDD. Striatal Aβ-immunoreactive plaques were only consistently found in cases with DLB and correlated with both the severity (positive correlation) and duration (negative correlation) of dementia. Striatal Aβ-immunoreactive plaques also positively correlated with the severity of α-synuclein-immunoreactive pathologies as well as cortical Aβ-positive plaques. Striatal Aβ deposition positively predicted dementia in Lewy body cases with high specificity and had the greatest sensitivity to differentiate DLB from PDD with 100% negative predictive value. These data suggest that striatal Aβ deposition in Lewy body diseases contributes to early dementia and in these cases may impact on the efficacy of treatments targeting the striatum. Springer-Verlag, 2011 Aβ plaque nationallicence Dementia nationallicence Lewy bodies nationallicence Parkinson's disease nationallicence Striatum nationallicence Halliday Glenda Neuroscience Research Australia, Barker Street, Randwick, 2031, Sydney, NSW, Australia aut Song Yun Neuroscience Research Australia, Barker Street, Randwick, 2031, Sydney, NSW, Australia aut Harding Antony Neuroscience Research Australia, Barker Street, Randwick, 2031, Sydney, NSW, Australia aut Journal of Neural Transmission Springer Vienna 118/5(2011-05-01), 713-719 0300-9564 118:5<713 2011 118 702 https://doi.org/10.1007/s00702-011-0641-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-011-0641-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Halliday Glenda Neuroscience Research Australia, Barker Street, Randwick, 2031, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Song Yun Neuroscience Research Australia, Barker Street, Randwick, 2031, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Harding Antony Neuroscience Research Australia, Barker Street, Randwick, 2031, Sydney, NSW, Australia aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/5(2011-05-01), 713-719 0300-9564 118:5<713 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer