caa a22 4500 445377577 CHVBK 20180317143007.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00702-010-0539-8 doi (NATIONALLICENCE)springer-10.1007/s00702-010-0539-8 Influence of brain-derived neurotrophic-factor and apolipoprotein E genetic variants on hippocampal volume and memory performance in healthy young adults [Elektronische Daten] [Tanja Richter-Schmidinger, Panagiotis Alexopoulos, Marco Horn, Sebastian Maus, Martin Reichel, Cosima Rhein, Piotr Lewczuk, Christos Sidiropoulos, Thomas Kneib, Robert Perneczky, Arnd Doerfler, Johannes Kornhuber] Unravelling the impact of genetic variants on clinical phenotypes is a challenging task. Apolipoprotein E (ApoE) and brain-derived neurotrophic factor (BDNF) play an important role in cell growth, regeneration, synaptic plasticity, learning and memory processes. The aim of the present study was to examine the impact of BDNF Val66Met- and ApoE-polymorphisms and their interactions on hippocampal morphology and memory functions in healthy young adults. Hippocampal volume and memory performance of 135 healthy individuals, aged 24.6±3.2years, were assessed, using magnetic resonance imaging and the Inventory for Memory diagnostics. The performance of BDNF-Met66 carriers was significantly lower in working memory (P=0.03) compared with non carriers, whereas no further differences were observed either in cognitive performance or in hippocampal volumes between the groups. Age, BDNF Val66 Met polymorphism and the interaction factor BDNF genotype x age were significantly associated with the variation of working memory scores (P=0.01, 0.01, 0.02 respectively). No statistically significant differences were detected in the volumes of hippocampi and in memory phenotypes between individuals carrying the ApoE E4 allele and those without it. The analysis did not reveal an impact of gene-gene interaction between BDNF and ApoE genes on hippocampal volumes or memory performance. BDNF Val66Met polymorphism seems to influence working memory function and modulate the effects of ageing on working memory in healthy young adults. Springer-Verlag, 2010 BDNF nationallicence ApoE nationallicence Hippocampus nationallicence Cognitive function nationallicence Richter-Schmidinger Tanja Department of Psychiatry and Psychotherapy, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany aut Alexopoulos Panagiotis Department of Psychiatry and Psychotherapy, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany aut Horn Marco Department of Psychiatry and Psychotherapy, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany aut Maus Sebastian Department of Psychiatry and Psychotherapy, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany aut Reichel Martin Department of Psychiatry and Psychotherapy, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany aut Rhein Cosima Department of Psychiatry and Psychotherapy, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany aut Lewczuk Piotr Department of Psychiatry and Psychotherapy, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany aut Sidiropoulos Christos Department of Psychiatry and Psychotherapy, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany aut Kneib Thomas Institute of Mathematics, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany aut Perneczky Robert Department of Psychiatry and Psychotherapy, Technische Universität München, Ismaninger Str. 22, 81675, Munich, Germany aut Doerfler Arnd Department of Neuroradiology, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany aut Kornhuber Johannes Department of Psychiatry and Psychotherapy, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany aut Journal of Neural Transmission Springer Vienna 118/2(2011-02-01), 249-257 0300-9564 118:2<249 2011 118 702 https://doi.org/10.1007/s00702-010-0539-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-010-0539-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Richter-Schmidinger Tanja Department of Psychiatry and Psychotherapy, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany aut NATIONALLICENCE 700 1- Alexopoulos Panagiotis Department of Psychiatry and Psychotherapy, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany aut NATIONALLICENCE 700 1- Horn Marco Department of Psychiatry and Psychotherapy, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany aut NATIONALLICENCE 700 1- Maus Sebastian Department of Psychiatry and Psychotherapy, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany aut NATIONALLICENCE 700 1- Reichel Martin Department of Psychiatry and Psychotherapy, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany aut NATIONALLICENCE 700 1- Rhein Cosima Department of Psychiatry and Psychotherapy, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany aut NATIONALLICENCE 700 1- Lewczuk Piotr Department of Psychiatry and Psychotherapy, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany aut NATIONALLICENCE 700 1- Sidiropoulos Christos Department of Psychiatry and Psychotherapy, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany aut NATIONALLICENCE 700 1- Kneib Thomas Institute of Mathematics, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany aut NATIONALLICENCE 700 1- Perneczky Robert Department of Psychiatry and Psychotherapy, Technische Universität München, Ismaninger Str. 22, 81675, Munich, Germany aut NATIONALLICENCE 700 1- Doerfler Arnd Department of Neuroradiology, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany aut NATIONALLICENCE 700 1- Kornhuber Johannes Department of Psychiatry and Psychotherapy, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/2(2011-02-01), 249-257 0300-9564 118:2<249 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer