caa a22 4500 445377631 CHVBK 20180317143007.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00702-010-0510-8 doi (NATIONALLICENCE)springer-10.1007/s00702-010-0510-8 Repetitive methylphenidate administration modulates the diurnal behavioral activity pattern of adult female SD rats [Elektronische Daten] [Min Lee, Pamela Yang, Victor Wilcox, Keith Burau, Alan Swann, Nachum Dafny] Diurnal rhythms influence many of the physiological processes that act to maintain homeostasis of the body in response to different environmental changes. Thus, disturbances in diurnal rhythms can lead to various physiological complications. Repeated exposure to psychostimulants may cause long-term effects by disturbing diurnal rhythms. The aim of the present study is to use the open field assay to determine whether repeated exposure to the psychostimulant methylphenidate (MPD) changes diurnal locomotor activity patterns of female adult Sprague-Dawley (SD) rats. As much as 31 female adult SD rats were divided into four groups. On experimental day (ED) 1, all groups were given an injection of saline. On ED 2-7, animals were injected once a day with either saline, or 0.6mg/kg MPD, or 2.5mg/kg MPD, or 10mg/kg MPD depending on the group. On ED 8-10, no injections were given (washout period). On ED 11, animals were treated as they were on ED 2-7. Locomotor movements were recorded using a computerized animal activity monitoring system. The horizontal activity (HA), total distance traveled (TDT), and number of stereotypies (NOS) were analyzed by cosine curve statistical analysis (CCSA) test. The HA and TDT diurnal rhythm activity patterns of ED 2, 7, 8, and 11 were significantly different (p<0.05) from the control recording of ED 1 according to the CCSA test. The observation obtained in this study suggests that repeated administration of MPD (all doses tested) is able to change diurnal locomotor patterns, which indicates that chronic MPD treatment exerts long-term effects. Springer-Verlag, 2010 Female SD rats nationallicence Circadian rhythmic activity nationallicence Behavior nationallicence Locomotor activity nationallicence Psychostimulant nationallicence Ritalin nationallicence Lee Min Department of Neurobiology and Anatomy, The University of Texas Medical School at Houston, P.O. Box 20708, 77225, Houston, TX, USA aut Yang Pamela Department of Anatomy and Neurobiology, The University of California Irvine School of Medicine, 92697, Irvine, CA, USA aut Wilcox Victor Department of Neurobiology and Anatomy, The University of Texas Medical School at Houston, P.O. Box 20708, 77225, Houston, TX, USA aut Burau Keith School of Public Health, Health Science Center at Houston, P.O. Box 20708, 77225, Houston, TX, USA aut Swann Alan Department of Psychiatry and Behavioral Sciences, The University of Texas Medical School at Houston, P.O. Box 20708, 77225, Houston, TX, USA aut Dafny Nachum Department of Neurobiology and Anatomy, The University of Texas Medical School at Houston, P.O. Box 20708, 77225, Houston, TX, USA aut Journal of Neural Transmission Springer Vienna 118/2(2011-02-01), 285-298 0300-9564 118:2<285 2011 118 702 https://doi.org/10.1007/s00702-010-0510-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-010-0510-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lee Min Department of Neurobiology and Anatomy, The University of Texas Medical School at Houston, P.O. Box 20708, 77225, Houston, TX, USA aut NATIONALLICENCE 700 1- Yang Pamela Department of Anatomy and Neurobiology, The University of California Irvine School of Medicine, 92697, Irvine, CA, USA aut NATIONALLICENCE 700 1- Wilcox Victor Department of Neurobiology and Anatomy, The University of Texas Medical School at Houston, P.O. Box 20708, 77225, Houston, TX, USA aut NATIONALLICENCE 700 1- Burau Keith School of Public Health, Health Science Center at Houston, P.O. Box 20708, 77225, Houston, TX, USA aut NATIONALLICENCE 700 1- Swann Alan Department of Psychiatry and Behavioral Sciences, The University of Texas Medical School at Houston, P.O. Box 20708, 77225, Houston, TX, USA aut NATIONALLICENCE 700 1- Dafny Nachum Department of Neurobiology and Anatomy, The University of Texas Medical School at Houston, P.O. Box 20708, 77225, Houston, TX, USA aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/2(2011-02-01), 285-298 0300-9564 118:2<285 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer