caa a22 4500 445377674 CHVBK 20180317143008.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00702-010-0519-z doi (NATIONALLICENCE)springer-10.1007/s00702-010-0519-z Cerebrospinal fluid under non-steady state condition caused by plasmapheresis [Elektronische Daten] [Dominik Madžar, Christian Maihöfner, Rüdiger Zimmermann, Stefan Schwab, Johannes Kornhuber, Piotr Lewczuk] We present an unusual constellation of the CSF/serum biomarkers of Guillain-Barré syndrome caused by unsteady-state condition of protein diffusion induced by plasmapheresis. Low blood concentrations of immunoglobulins were accompanied by their normal concentrations in the CSF, and hence the corresponding CSF/serum quotients seemed ‘increased' suggesting intrathecal humoral response. This was in contrast to the results of isoelectrofocusing showing identical IgG bands pattern in the CSF and serum. Control lumbar puncture performed 6weeks after the cessation of plasmapheresis, revealed normalization of the immunoglobulins' quotients. It must be stressed that the results of the CSF/serum analysis performed under non-steady state condition may be easily misinterpreted, and only considering the whole pattern of the CSF/serum biomarkers can assure correct interpretation of the results. Springer-Verlag, 2010 Guillain-Barré syndrome nationallicence Plasmapheresis nationallicence Cerebrospinal fluid nationallicence Intrathecal protein synthesis nationallicence Madžar Dominik Department of Neurology, Universitätsklinikum Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany aut Maihöfner Christian Department of Neurology, Universitätsklinikum Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany aut Zimmermann Rüdiger Lab for Clinical Neurochemistry and Neurochemical Dementia Diagnostics, Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany aut Schwab Stefan Department of Neurology, Universitätsklinikum Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany aut Kornhuber Johannes Lab for Clinical Neurochemistry and Neurochemical Dementia Diagnostics, Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany aut Lewczuk Piotr Lab for Clinical Neurochemistry and Neurochemical Dementia Diagnostics, Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany aut Journal of Neural Transmission Springer Vienna 118/2(2011-02-01), 219-222 0300-9564 118:2<219 2011 118 702 https://doi.org/10.1007/s00702-010-0519-z text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-010-0519-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Madžar Dominik Department of Neurology, Universitätsklinikum Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany aut NATIONALLICENCE 700 1- Maihöfner Christian Department of Neurology, Universitätsklinikum Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany aut NATIONALLICENCE 700 1- Zimmermann Rüdiger Lab for Clinical Neurochemistry and Neurochemical Dementia Diagnostics, Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany aut NATIONALLICENCE 700 1- Schwab Stefan Department of Neurology, Universitätsklinikum Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany aut NATIONALLICENCE 700 1- Kornhuber Johannes Lab for Clinical Neurochemistry and Neurochemical Dementia Diagnostics, Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany aut NATIONALLICENCE 700 1- Lewczuk Piotr Lab for Clinical Neurochemistry and Neurochemical Dementia Diagnostics, Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/2(2011-02-01), 219-222 0300-9564 118:2<219 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer