caa a22 4500 445377690 CHVBK 20180317143008.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00702-010-0534-0 doi (NATIONALLICENCE)springer-10.1007/s00702-010-0534-0 Different profiles of Alzheimer's disease cerebrospinal fluid biomarkers in controls and subjects with subjective memory complaints [Elektronische Daten] [Anna Antonell, Juan Fortea, Lorena Rami, Beatriz Bosch, Mircea Balasa, Raquel Sánchez-Valle, Alex Iranzo, José Molinuevo, Albert Lladó] Cerebrospinal fluid (CSF) biomarkers, such as Aβ42, total-tau and phosphorylated-tau181 reflect neuropathological changes of Alzheimer's disease (AD). We studied these biomarkers in 24 controls and 19 subjects with subjective memory complaints, and we distinguished different CSF profiles: normal (group 1, 55.8%), only pathologic Aβ42 (group 2, 27.9%), pathologic Aβ42 plus pathologic total-tau and/or phosphorylated-tau181 (group 3, 7%), and only pathologic total-tau and phosphorylated-tau181 (group 4, 9.3%). Group 2 could represent an earlier phase of preclinical AD than group 3, and group 4 an unknown etiology. Springer-Verlag, 2010 Alzheimer's disease nationallicence CSF nationallicence Biomarker nationallicence Cognitively normal subjects nationallicence Subjective memory complaint nationallicence Antonell Anna Alzheimer's disease and other cognitive disorders unit, Neurology Service, Hospital Clínic, Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), C/Villarroel, 170, 08036, Barcelona, Spain aut Fortea Juan Alzheimer's disease and other cognitive disorders unit, Neurology Service, Hospital Clínic, Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), C/Villarroel, 170, 08036, Barcelona, Spain aut Rami Lorena Alzheimer's disease and other cognitive disorders unit, Neurology Service, Hospital Clínic, Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), C/Villarroel, 170, 08036, Barcelona, Spain aut Bosch Beatriz Alzheimer's disease and other cognitive disorders unit, Neurology Service, Hospital Clínic, Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), C/Villarroel, 170, 08036, Barcelona, Spain aut Balasa Mircea Alzheimer's disease and other cognitive disorders unit, Neurology Service, Hospital Clínic, Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), C/Villarroel, 170, 08036, Barcelona, Spain aut Sánchez-Valle Raquel Alzheimer's disease and other cognitive disorders unit, Neurology Service, Hospital Clínic, Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), C/Villarroel, 170, 08036, Barcelona, Spain aut Iranzo Alex Multidisciplinary sleep unit, Neurology Service, Hospital Clínic, Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), CIBERNED, Barcelona, Spain aut Molinuevo José Alzheimer's disease and other cognitive disorders unit, Neurology Service, Hospital Clínic, Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), C/Villarroel, 170, 08036, Barcelona, Spain aut Lladó Albert Alzheimer's disease and other cognitive disorders unit, Neurology Service, Hospital Clínic, Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), C/Villarroel, 170, 08036, Barcelona, Spain aut Journal of Neural Transmission Springer Vienna 118/2(2011-02-01), 259-262 0300-9564 118:2<259 2011 118 702 https://doi.org/10.1007/s00702-010-0534-0 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-010-0534-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Antonell Anna Alzheimer's disease and other cognitive disorders unit, Neurology Service, Hospital Clínic, Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), C/Villarroel, 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Fortea Juan Alzheimer's disease and other cognitive disorders unit, Neurology Service, Hospital Clínic, Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), C/Villarroel, 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Rami Lorena Alzheimer's disease and other cognitive disorders unit, Neurology Service, Hospital Clínic, Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), C/Villarroel, 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Bosch Beatriz Alzheimer's disease and other cognitive disorders unit, Neurology Service, Hospital Clínic, Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), C/Villarroel, 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Balasa Mircea Alzheimer's disease and other cognitive disorders unit, Neurology Service, Hospital Clínic, Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), C/Villarroel, 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Sánchez-Valle Raquel Alzheimer's disease and other cognitive disorders unit, Neurology Service, Hospital Clínic, Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), C/Villarroel, 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Iranzo Alex Multidisciplinary sleep unit, Neurology Service, Hospital Clínic, Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), CIBERNED, Barcelona, Spain aut NATIONALLICENCE 700 1- Molinuevo José Alzheimer's disease and other cognitive disorders unit, Neurology Service, Hospital Clínic, Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), C/Villarroel, 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Lladó Albert Alzheimer's disease and other cognitive disorders unit, Neurology Service, Hospital Clínic, Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), C/Villarroel, 170, 08036, Barcelona, Spain aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/2(2011-02-01), 259-262 0300-9564 118:2<259 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer