caa a22 4500 445377704 CHVBK 20180317143008.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00702-010-0525-1 doi (NATIONALLICENCE)springer-10.1007/s00702-010-0525-1 Interferon-gamma (+874) T/A genotypes and risk of IFN-alpha-induced depression [Elektronische Daten] [G. Oxenkrug, M. Perianayagam, D. Mikolich, P. Requintina, L. Shick, R. Ruthazer, D. Zucker, P. Summergrad] Depression is a frequent side effect of interferon (IFN)-alpha therapy of hepatitis C (HCV) and is of great relevance with regard to adherence, compliance, and premature therapy discontinuation. There are no reliable tests to identify patients-at-risk for the development of IFN-alpha induced depression. We retrospectively studied distribution of IFN-gamma (IFNG) (+874) T/A genotypes in 170 Caucasian HCV patients treated by IFN-alpha. Distribution of IFNG (+874) genotypes was different between depressed and not depressed subjects with more TA and less AA carriers among depressed than among not depressed subjects (P=0.003). Carriers with at least one T allele were more frequent among depressed than among not depressed patients (P=0.003). Our results suggest that presence of high producer (T) alleles might be a genetic risk factor for the development of IFN-alpha-induced depression. Assessment of IFNG (+874) genotypes might help to identify patients-at-risk for IFN-alpha-induced depression. IFNG and IFN-alpha transcriptionally induce indoleamine-2,3-dioxygenase (IDO), the rate-limiting enzyme of the kynurenine (KYN) pathway of tryptophan (TRY) metabolism. IFN-induced up-regulation of IDO triggers depression by shifting TRY metabolism from formation of serotonin to production of neuroactive kynurenines. TRY-KYN pathway might be a new target for pharmacological prevention and treatment of IFN-alpha-induced psychiatric complications. Springer-Verlag, 2010 Interferon-gamma (+874) polymorphism nationallicence Depression nationallicence Hepatitis C nationallicence Kynurenines nationallicence Oxenkrug G. Psychiatry and Inflammation Program, Department of Psychiatry, Tufts University School of Medicine, Boston, MA, USA aut Perianayagam M. Psychiatry and Inflammation Program, Department of Psychiatry, Tufts University School of Medicine, Boston, MA, USA aut Mikolich D. Psychiatry and Inflammation Program, Department of Psychiatry, Tufts University School of Medicine, Boston, MA, USA aut Requintina P. Psychiatry and Inflammation Program, Department of Psychiatry, Tufts University School of Medicine, Boston, MA, USA aut Shick L. Psychiatry and Inflammation Program, Department of Psychiatry, Tufts University School of Medicine, Boston, MA, USA aut Ruthazer R. Psychiatry and Inflammation Program, Department of Psychiatry, Tufts University School of Medicine, Boston, MA, USA aut Zucker D. Psychiatry and Inflammation Program, Department of Psychiatry, Tufts University School of Medicine, Boston, MA, USA aut Summergrad P. Psychiatry and Inflammation Program, Department of Psychiatry, Tufts University School of Medicine, Boston, MA, USA aut Journal of Neural Transmission Springer Vienna 118/2(2011-02-01), 271-274 0300-9564 118:2<271 2011 118 702 https://doi.org/10.1007/s00702-010-0525-1 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-010-0525-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Oxenkrug G. Psychiatry and Inflammation Program, Department of Psychiatry, Tufts University School of Medicine, Boston, MA, USA aut NATIONALLICENCE 700 1- Perianayagam M. Psychiatry and Inflammation Program, Department of Psychiatry, Tufts University School of Medicine, Boston, MA, USA aut NATIONALLICENCE 700 1- Mikolich D. Psychiatry and Inflammation Program, Department of Psychiatry, Tufts University School of Medicine, Boston, MA, USA aut NATIONALLICENCE 700 1- Requintina P. Psychiatry and Inflammation Program, Department of Psychiatry, Tufts University School of Medicine, Boston, MA, USA aut NATIONALLICENCE 700 1- Shick L. Psychiatry and Inflammation Program, Department of Psychiatry, Tufts University School of Medicine, Boston, MA, USA aut NATIONALLICENCE 700 1- Ruthazer R. Psychiatry and Inflammation Program, Department of Psychiatry, Tufts University School of Medicine, Boston, MA, USA aut NATIONALLICENCE 700 1- Zucker D. Psychiatry and Inflammation Program, Department of Psychiatry, Tufts University School of Medicine, Boston, MA, USA aut NATIONALLICENCE 700 1- Summergrad P. Psychiatry and Inflammation Program, Department of Psychiatry, Tufts University School of Medicine, Boston, MA, USA aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/2(2011-02-01), 271-274 0300-9564 118:2<271 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer