caa a22 4500 445377747 CHVBK 20180317143008.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00702-010-0502-8 doi (NATIONALLICENCE)springer-10.1007/s00702-010-0502-8 Aversive memory in sepsis survivor rats [Elektronische Daten] [Clarissa Comim, Larissa Constantino, Fabricia Petronilho, João Quevedo, Felipe Dal-Pizzol] Sepsis is an infectious insult resulting in disturbances in the normal regulation of many organic systems, including the central nervous system. This study aims to evaluate aversive memory as well as its variances—posttraumatic memory and memory of extinction—in survivor rats submitted to sepsis by cecal ligation and perforation (CLP) at 10, 30, and 60days after CLP, utilizing the inhibitory avoidance (IA) task paradigm. Male Wistar rats underwent either CLP or sham surgery under anesthesia. Sepsis group received antibiotics and fluid support, whereas sham group received only fluid replacement. The rats were divided in four different tasks: (1) aversive memory after 10, 30, and 60days after CLP; (2) memory of extinction 60days after CLP; (3) aversive memory-two trainings paradigm 10days after CLP; and (4) posttraumatic memory 10days after CLP. The aversive memory was impaired at 10, 30, but not 60days after CLP, However, no damage was found in aversive memory after two training sessions. Additionally, there was no damage to the memory of extinction 60days after CLP. Posttraumatic memory impairment was also observed. In this regard, we believe that our results provide relevant insights into the mechanisms involved in the cognitive deficits associated with sepsis. Springer-Verlag, 2010 Sepsis nationallicence Brain nationallicence Aversive memory nationallicence Rat nationallicence Comim Clarissa Laboratory of Neurosciences and National Institute for Translational Medicine (INCT-TM), Postgradute Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, 88806-000, Criciúma, SC, Brazil aut Constantino Larissa Laboratory of Experimental Pathophysiology and National Institute for Translational Medicine (INCT-TM), Postgradute Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, 88806-000, Criciúma, SC, Brazil aut Petronilho Fabricia Laboratory of Experimental Pathophysiology and National Institute for Translational Medicine (INCT-TM), Postgradute Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, 88806-000, Criciúma, SC, Brazil aut Quevedo João Laboratory of Neurosciences and National Institute for Translational Medicine (INCT-TM), Postgradute Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, 88806-000, Criciúma, SC, Brazil aut Dal-Pizzol Felipe Laboratory of Experimental Pathophysiology and National Institute for Translational Medicine (INCT-TM), Postgradute Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, 88806-000, Criciúma, SC, Brazil aut Journal of Neural Transmission Springer Vienna 118/2(2011-02-01), 213-217 0300-9564 118:2<213 2011 118 702 https://doi.org/10.1007/s00702-010-0502-8 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-010-0502-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Comim Clarissa Laboratory of Neurosciences and National Institute for Translational Medicine (INCT-TM), Postgradute Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, 88806-000, Criciúma, SC, Brazil aut NATIONALLICENCE 700 1- Constantino Larissa Laboratory of Experimental Pathophysiology and National Institute for Translational Medicine (INCT-TM), Postgradute Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, 88806-000, Criciúma, SC, Brazil aut NATIONALLICENCE 700 1- Petronilho Fabricia Laboratory of Experimental Pathophysiology and National Institute for Translational Medicine (INCT-TM), Postgradute Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, 88806-000, Criciúma, SC, Brazil aut NATIONALLICENCE 700 1- Quevedo João Laboratory of Neurosciences and National Institute for Translational Medicine (INCT-TM), Postgradute Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, 88806-000, Criciúma, SC, Brazil aut NATIONALLICENCE 700 1- Dal-Pizzol Felipe Laboratory of Experimental Pathophysiology and National Institute for Translational Medicine (INCT-TM), Postgradute Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, 88806-000, Criciúma, SC, Brazil aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/2(2011-02-01), 213-217 0300-9564 118:2<213 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer