caa a22 4500 445377755 CHVBK 20180317143008.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00702-011-0640-7 doi (NATIONALLICENCE)springer-10.1007/s00702-011-0640-7 Valeriana officinalis ameliorates vacuous chewing movements induced by reserpine in rats [Elektronische Daten] [Romaiana Pereira, Roselei Fachinetto, Alessandro de Souza Prestes, Caroline Wagner, Jéssie Sudati, Aline Boligon, Margareth Athayde, Vera Morsch, João Rocha] Oral movements are associated with important neuropathologies as Parkinson's disease and tardive dyskinesia. However, until this time, there has been no known efficacious treatment, without side effects, for these disorders. Thus, the aim of the present study was to investigate the possible preventive effects of V. officinalis, a phytotherapic that has GABAergic and antioxidant properties, in vacuous chewing movements (VCMs) induced by reserpine in rats. Adult male rats were treated with reserpine (1mg/kg, s.c.) and/or with V. officinalis (in the drinking water, starting 15days before the administration of the reserpine). VCMs, locomotor activity and oxidative stress measurements were evaluated. Furthermore, we carried out the identification of valeric acid and gallic acid by HPLC in the V. officinalis tincture. Our findings demonstrated that reserpine caused a marked increase on VCMs and the co-treatment with V. officinalis was able to reduce the intensity of VCM. Reserpine did not induce oxidative stress in cerebral structures (cortex, hippocampus, striatum and substantia nigra). However, a significant positive correlation between DCF-oxidation (an estimation of oxidative stress) in the cortex and VCMs (p<0.05) was observed. Moreover, a negative correlation between Na+K+-ATPase activity in substantia nigra and the number of VCMs was observed (p<0.05). In conclusion, V. officinalis had behavioral protective effect against reserpine-induced VCMs in rats; however, the exact mechanisms that contributed to this effect have not been completely understood. Springer-Verlag, 2011 Oral dyskinesia nationallicence Parkinson's disease nationallicence Reserpine nationallicence Vacuous chewing movements nationallicence Valeriana officinalis nationallicence Tardive dyskinesia : TD nationallicence Parkinson's disease : PD nationallicence Vacuous chewing movements : VCMs nationallicence Orofacial dyskinesia : OD nationallicence Monoaminoxidase : MAO nationallicence Valeriana officinalis : V. officinalis nationallicence Reactive oxygen species : ROS nationallicence 2′,7′-Dichlorodihydrofluorescein diacetate : DCFH-DA nationallicence Thiobarbituric acid reactive substances : TBARS nationallicence Pereira Romaiana Departamento de Química, Programa de Pós-Graduação em Bioquímica Toxicológica, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil aut Fachinetto Roselei Departamento de Fisiologia e Farmacologia, Programa de Pós-Graduação em Farmacologia, and Programa de Pós-Graduação em Bioquímica Toxicológica, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil aut de Souza Prestes Alessandro Departamento de Química, Programa de Pós-Graduação em Bioquímica Toxicológica, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil aut Wagner Caroline Departamento de Química, Programa de Pós-Graduação em Bioquímica Toxicológica, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil aut Sudati Jéssie Departamento de Química, Programa de Pós-Graduação em Bioquímica Toxicológica, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil aut Boligon Aline Departamento de Farmácia Industrial, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil aut Athayde Margareth Departamento de Farmácia Industrial, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil aut Morsch Vera Departamento de Química, Programa de Pós-Graduação em Bioquímica Toxicológica, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil aut Rocha João Departamento de Química, Programa de Pós-Graduação em Bioquímica Toxicológica, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil aut Journal of Neural Transmission Springer Vienna 118/11(2011-11-01), 1547-1557 0300-9564 118:11<1547 2011 118 702 https://doi.org/10.1007/s00702-011-0640-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-011-0640-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pereira Romaiana Departamento de Química, Programa de Pós-Graduação em Bioquímica Toxicológica, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil aut NATIONALLICENCE 700 1- Fachinetto Roselei Departamento de Fisiologia e Farmacologia, Programa de Pós-Graduação em Farmacologia, and Programa de Pós-Graduação em Bioquímica Toxicológica, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil aut NATIONALLICENCE 700 1- de Souza Prestes Alessandro Departamento de Química, Programa de Pós-Graduação em Bioquímica Toxicológica, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil aut NATIONALLICENCE 700 1- Wagner Caroline Departamento de Química, Programa de Pós-Graduação em Bioquímica Toxicológica, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil aut NATIONALLICENCE 700 1- Sudati Jéssie Departamento de Química, Programa de Pós-Graduação em Bioquímica Toxicológica, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil aut NATIONALLICENCE 700 1- Boligon Aline Departamento de Farmácia Industrial, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil aut NATIONALLICENCE 700 1- Athayde Margareth Departamento de Farmácia Industrial, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil aut NATIONALLICENCE 700 1- Morsch Vera Departamento de Química, Programa de Pós-Graduação em Bioquímica Toxicológica, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil aut NATIONALLICENCE 700 1- Rocha João Departamento de Química, Programa de Pós-Graduação em Bioquímica Toxicológica, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/11(2011-11-01), 1547-1557 0300-9564 118:11<1547 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer