caa a22 4500 44537778X CHVBK 20180317143008.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00702-011-0636-3 doi (NATIONALLICENCE)springer-10.1007/s00702-011-0636-3 Increase expression of α-synuclein in aged human brain associated with neuromelanin accumulation [Elektronische Daten] [Qi Xuan, Sheng-Li Xu, De-Hong Lu, Shun Yu, Ming Zhou, Kenji Uéda, Ye-Qing Cui, Bo-Yang Zhang, Piu Chan] Although the increased prevalence of Parkinson's disease (PD) with aging suggests that aging processes predispose dopamine neurons to degeneration, the mechanism involved remains unknown. Dopamine neurons contain significant amounts of neuromelanin, and the amount of neuromelanin increases with aging. In the present study, age-related changes in the number of nigral neurons expressing neuromelanin (NM), α-synuclein, and tyrosine hydroxylase (TH) were stereologically analyzed in the postmortem brains of 28 healthy humans with an age range of 17-84years. Stereological counting of NM content, α-synuclein content, and TH immunoreactivity revealed significant accumulation of NM and α-synuclein in neurons during the aging process. In cells containing a large amount of NM, α-synuclein-immunoreactive cells in aged individuals outnumbered those of younger individuals. In non-NM cells, the α-synuclein expression profile was similar across age groups. Furthermore, TH-immunoreactive neurons decreased significantly with aging, which was associated with accumulation of NM and α-synuclein. Our results suggest that age related accumulation of NM might induce α-synuclein over-expression and thereby make dopamine neurons more vulnerable to injuries. Springer-Verlag, 2011 Aging nationallicence α-Synuclein nationallicence Tyrosine hydroxylase nationallicence Neuromelanin nationallicence Xuan Qi Department of Neurobiology and the Sino-Japan Joint Laboratory of Neurodegenerative diseases, Institute of Geriatrics of Beijing, Xuanwu Hospital of the Capital University of Medical Sciences, Key Laboratory for Neurodegenerative Disease of Ministry of Education, 45 Changchun Street, 100053, Beijing, China aut Xu Sheng-Li Department of Neurobiology and the Sino-Japan Joint Laboratory of Neurodegenerative diseases, Institute of Geriatrics of Beijing, Xuanwu Hospital of the Capital University of Medical Sciences, Key Laboratory for Neurodegenerative Disease of Ministry of Education, 45 Changchun Street, 100053, Beijing, China aut Lu De-Hong Department of Pathology, Xuanwu Hospital of the Capital University of Medical Sciences, 45 Changchun Street, 100053, Beijing, China aut Yu Shun Department of Neurobiology and the Sino-Japan Joint Laboratory of Neurodegenerative diseases, Institute of Geriatrics of Beijing, Xuanwu Hospital of the Capital University of Medical Sciences, Key Laboratory for Neurodegenerative Disease of Ministry of Education, 45 Changchun Street, 100053, Beijing, China aut Zhou Ming Department of Neurobiology and the Sino-Japan Joint Laboratory of Neurodegenerative diseases, Institute of Geriatrics of Beijing, Xuanwu Hospital of the Capital University of Medical Sciences, Key Laboratory for Neurodegenerative Disease of Ministry of Education, 45 Changchun Street, 100053, Beijing, China aut Uéda Kenji Department of Neurobiology and the Sino-Japan Joint Laboratory of Neurodegenerative diseases, Institute of Geriatrics of Beijing, Xuanwu Hospital of the Capital University of Medical Sciences, Key Laboratory for Neurodegenerative Disease of Ministry of Education, 45 Changchun Street, 100053, Beijing, China aut Cui Ye-Qing Department of General Surgery, Xuanwu Hospital of the Capital University of Medical Sciences, 45 Changchun Street, 100053, Beijing, China aut Zhang Bo-Yang Forensic Medical Examination and Identification Center, Beijing Public Security Bureau, 100085, Beijing, China aut Chan Piu Department of Neurobiology and the Sino-Japan Joint Laboratory of Neurodegenerative diseases, Institute of Geriatrics of Beijing, Xuanwu Hospital of the Capital University of Medical Sciences, Key Laboratory for Neurodegenerative Disease of Ministry of Education, 45 Changchun Street, 100053, Beijing, China aut Journal of Neural Transmission Springer Vienna 118/11(2011-11-01), 1575-1583 0300-9564 118:11<1575 2011 118 702 https://doi.org/10.1007/s00702-011-0636-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-011-0636-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Xuan Qi Department of Neurobiology and the Sino-Japan Joint Laboratory of Neurodegenerative diseases, Institute of Geriatrics of Beijing, Xuanwu Hospital of the Capital University of Medical Sciences, Key Laboratory for Neurodegenerative Disease of Ministry of Education, 45 Changchun Street, 100053, Beijing, China aut NATIONALLICENCE 700 1- Xu Sheng-Li Department of Neurobiology and the Sino-Japan Joint Laboratory of Neurodegenerative diseases, Institute of Geriatrics of Beijing, Xuanwu Hospital of the Capital University of Medical Sciences, Key Laboratory for Neurodegenerative Disease of Ministry of Education, 45 Changchun Street, 100053, Beijing, China aut NATIONALLICENCE 700 1- Lu De-Hong Department of Pathology, Xuanwu Hospital of the Capital University of Medical Sciences, 45 Changchun Street, 100053, Beijing, China aut NATIONALLICENCE 700 1- Yu Shun Department of Neurobiology and the Sino-Japan Joint Laboratory of Neurodegenerative diseases, Institute of Geriatrics of Beijing, Xuanwu Hospital of the Capital University of Medical Sciences, Key Laboratory for Neurodegenerative Disease of Ministry of Education, 45 Changchun Street, 100053, Beijing, China aut NATIONALLICENCE 700 1- Zhou Ming Department of Neurobiology and the Sino-Japan Joint Laboratory of Neurodegenerative diseases, Institute of Geriatrics of Beijing, Xuanwu Hospital of the Capital University of Medical Sciences, Key Laboratory for Neurodegenerative Disease of Ministry of Education, 45 Changchun Street, 100053, Beijing, China aut NATIONALLICENCE 700 1- Uéda Kenji Department of Neurobiology and the Sino-Japan Joint Laboratory of Neurodegenerative diseases, Institute of Geriatrics of Beijing, Xuanwu Hospital of the Capital University of Medical Sciences, Key Laboratory for Neurodegenerative Disease of Ministry of Education, 45 Changchun Street, 100053, Beijing, China aut NATIONALLICENCE 700 1- Cui Ye-Qing Department of General Surgery, Xuanwu Hospital of the Capital University of Medical Sciences, 45 Changchun Street, 100053, Beijing, China aut NATIONALLICENCE 700 1- Zhang Bo-Yang Forensic Medical Examination and Identification Center, Beijing Public Security Bureau, 100085, Beijing, China aut NATIONALLICENCE 700 1- Chan Piu Department of Neurobiology and the Sino-Japan Joint Laboratory of Neurodegenerative diseases, Institute of Geriatrics of Beijing, Xuanwu Hospital of the Capital University of Medical Sciences, Key Laboratory for Neurodegenerative Disease of Ministry of Education, 45 Changchun Street, 100053, Beijing, China aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/11(2011-11-01), 1575-1583 0300-9564 118:11<1575 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer