caa a22 4500 445377798 CHVBK 20180317143008.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00702-011-0679-5 doi (NATIONALLICENCE)springer-10.1007/s00702-011-0679-5 Dream features in the early stages of Parkinson's Disease [Elektronische Daten] [Paulo Bugalho, Teresa Paiva] Few studies have investigated the relation between dream features and cognition in Parkinson's disease (PD), although vivid dreams, hallucinations and cognitive decline have been proposed as successive steps of a pathological continuum. Our objectives were therefore to characterize the dreams of early stage PD and to study the relation between dream characteristics, cognitive function, motor status, depression, dopaminergic treatment, and the presence of REM sleep behaviour disorder (RBD) and hallucinations. Dreams of 19 male PD patients and 21 matched control subjects were classified according to Hall and van de Castle system. h statistics was used to compare the dream content between patients and controls. We tested the relation between patients' dreams characteristics and cognitive function (Frontal assessment battery (FAB) and Mini-Mental State Examination tests) depression (Beck depression inventory), motor function (UPDRS), dopaminergic treatment, the presence of RBD (according to clinical criteria) and hallucinations, using general linear model statistics. Patients and controls differed only on FAB scores. Relevant differences in the Hall and van de Castle scale were found between patient's dreams and those of the control group, regarding animals, aggression/friendliness, physical aggression, befriender (higher in the patient group) and aggressor and bodily misfortunes (lower in the patient group) features. Cognitive and particularly frontal dysfunction had a significant influence on the frequency of physical aggression and animal related features, while dopaminergic doses, depressive symptoms, hallucinations and RBD did not. We found a pattern of dream alteration characterized by heightened aggressiveness and the presence of animals. These were related to more severe frontal dysfunction, which could be the origin of such changes. Springer-Verlag, 2011 Parkinson's disease nationallicence Early stage nationallicence Dreaming nationallicence Pre-frontal function nationallicence Bugalho Paulo Neurology Department Hospital de Egas Moniz (CHLO), Rua da Junqueira, 126, 1349-019, Lisbon, Portugal aut Paiva Teresa Faculty of Medicine, Hospital Santa Maria, Lisbon, Portugal aut Journal of Neural Transmission Springer Vienna 118/11(2011-11-01), 1613-1619 0300-9564 118:11<1613 2011 118 702 https://doi.org/10.1007/s00702-011-0679-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-011-0679-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bugalho Paulo Neurology Department Hospital de Egas Moniz (CHLO), Rua da Junqueira, 126, 1349-019, Lisbon, Portugal aut NATIONALLICENCE 700 1- Paiva Teresa Faculty of Medicine, Hospital Santa Maria, Lisbon, Portugal aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/11(2011-11-01), 1613-1619 0300-9564 118:11<1613 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer