caa a22 4500 445377887 CHVBK 20180317143008.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00702-011-0672-z doi (NATIONALLICENCE)springer-10.1007/s00702-011-0672-z Neurocognitive-genetic and neuroimaging-genetic research paradigms in schizophrenia and bipolar disorder [Elektronische Daten] [Yoanna Kurnianingsih, Carissa Kuswanto, Roger McIntyre, Anqi Qiu, Beng Ho, Kang Sim] Studies examining intermediate phenotypes such as neurocognitive and neuroanatomical measures along with susceptibility genes are important for improving our understanding of the neural basis of schizophrenia (SZ) and bipolar disorder (BD). In this paper, we review extant studies involving neurocognitive-genetic and neuroimaging-genetic perspectives and particularly related to catechol-O-methyltransferase (COMT), brain-derived neurotrophic factor (BDNF) and neuregulin-1 (NRG1) genes in SZ and BD. In terms of neurocognitive-genetic investigations, COMT and BDNF are the two most studied candidate genes especially in patients with SZ. Whereas BDNF Met carriers perform worse on verbal working memory, problem solving and visuo-spatial abilities, COMT Met carriers perform better in working memory, attention, executive functioning with evidence of genotype by diagnosis interactions including high-risk individuals. In terms of genetic-structural MRI studies, patients with SZ are found to have reductions in the frontal, temporal, parietal cortices, and limbic regions, which are associated with BDNF, COMT, and NRGI genes. Genetic-functional MRI studies in psychotic disorders are sparse, especially with regard to BD. These neurocognitive and neuroimaging findings are associated with genes which are implicated in functional pathways related to neuronal signaling, inter-neuronal communication and neuroplasticity. Springer-Verlag, 2011 Schizophrenia nationallicence Bipolar disorder nationallicence Genetic nationallicence Neuroimaging nationallicence Neurocognitive nationallicence Kurnianingsih Yoanna Institute of Mental Health, Woodbridge Hospital, 10, Buangkok View, 539747, Singapore, Singapore aut Kuswanto Carissa Institute of Mental Health, Woodbridge Hospital, 10, Buangkok View, 539747, Singapore, Singapore aut McIntyre Roger University Health Network, University of Toronto, Toronto, Canada aut Qiu Anqi Department of Bioengineering/Clinical Imaging Research Center, National University of Singapore, Singapore, Singapore aut Ho Beng Department of Psychiatry, University of Iowa, Iowa City, USA aut Sim Kang Institute of Mental Health, Woodbridge Hospital, 10, Buangkok View, 539747, Singapore, Singapore aut Journal of Neural Transmission Springer Vienna 118/11(2011-11-01), 1621-1639 0300-9564 118:11<1621 2011 118 702 https://doi.org/10.1007/s00702-011-0672-z text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-011-0672-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kurnianingsih Yoanna Institute of Mental Health, Woodbridge Hospital, 10, Buangkok View, 539747, Singapore, Singapore aut NATIONALLICENCE 700 1- Kuswanto Carissa Institute of Mental Health, Woodbridge Hospital, 10, Buangkok View, 539747, Singapore, Singapore aut NATIONALLICENCE 700 1- McIntyre Roger University Health Network, University of Toronto, Toronto, Canada aut NATIONALLICENCE 700 1- Qiu Anqi Department of Bioengineering/Clinical Imaging Research Center, National University of Singapore, Singapore, Singapore aut NATIONALLICENCE 700 1- Ho Beng Department of Psychiatry, University of Iowa, Iowa City, USA aut NATIONALLICENCE 700 1- Sim Kang Institute of Mental Health, Woodbridge Hospital, 10, Buangkok View, 539747, Singapore, Singapore aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/11(2011-11-01), 1621-1639 0300-9564 118:11<1621 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer