caa a22 4500 44537814X CHVBK 20180317143009.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s10393-011-0717-7 doi (NATIONALLICENCE)springer-10.1007/s10393-011-0717-7 Phylogeny, Life History, and Ecology Contribute to Differences in Amphibian Susceptibility to Ranaviruses [Elektronische Daten] [Jason Hoverman, Matthew Gray, Nathan Haislip, Debra Miller] Research that identifies the potential host range of generalist pathogens as well as variation in host susceptibility is critical for understanding and predicting the dynamics of infectious diseases within ecological communities. Ranaviruses have been linked to amphibian die-off events worldwide with the greatest number of reported mortality events occurring in the United States. While reports of ranavirus-associated mortality events continue to accumulate, few data exist comparing the relative susceptibility of different species. Using a series of laboratory exposure experiments and comparative phylogenetics, we compared the susceptibilities of 19 amphibian species from two salamander families and five anurans families for two ranavirus isolates: frog virus 3 (FV3) and an FV3-like isolate from an American bullfrog culture facility. We discovered that ranaviruses were capable of infecting 17 of the 19 larval amphibian species tested with mortality ranging from 0 to 100%. Phylogenetic comparative methods demonstrated that species within the anuran family Ranidae were generally more susceptible to ranavirus infection compared to species from the other five families. We also found that susceptibility to infection was associated with species that breed in semi-permanent ponds, develop rapidly as larvae, and have limited range sizes. Collectively, these results suggest that phylogeny, life history characteristics, and habitat associations of amphibians have the potential to impact susceptibility to ranaviruses. International Association for Ecology and Health, 2011 Anura nationallicence Caudata nationallicence Emerging infectious disease nationallicence Frog virus 3 nationallicence Iridoviridae nationallicence Novel strain nationallicence Phylogeny nationallicence Reservoir nationallicence Hoverman Jason Department of Ecology and Evolutionary Biology, University of Colorado, 80309, Boulder, CO, USA aut Gray Matthew Center for Wildlife Health, Department of Forestry, Wildlife, and Fisheries, University of Tennessee, Knoxville, USA aut Haislip Nathan Center for Wildlife Health, Department of Forestry, Wildlife, and Fisheries, University of Tennessee, Knoxville, USA aut Miller Debra Center for Wildlife Health, Department of Forestry, Wildlife, and Fisheries, University of Tennessee, Knoxville, USA aut EcoHealth Springer-Verlag 8/3(2011-09-01), 301-319 1612-9202 8:3<301 2011 8 10393 https://doi.org/10.1007/s10393-011-0717-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10393-011-0717-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hoverman Jason Department of Ecology and Evolutionary Biology, University of Colorado, 80309, Boulder, CO, USA aut NATIONALLICENCE 700 1- Gray Matthew Center for Wildlife Health, Department of Forestry, Wildlife, and Fisheries, University of Tennessee, Knoxville, USA aut NATIONALLICENCE 700 1- Haislip Nathan Center for Wildlife Health, Department of Forestry, Wildlife, and Fisheries, University of Tennessee, Knoxville, USA aut NATIONALLICENCE 700 1- Miller Debra Center for Wildlife Health, Department of Forestry, Wildlife, and Fisheries, University of Tennessee, Knoxville, USA aut NATIONALLICENCE 773 0- EcoHealth Springer-Verlag 8/3(2011-09-01), 301-319 1612-9202 8:3<301 2011 8 10393 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer