caa a22 4500 445385197 CHVBK 20180317143030.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10924-011-0334-0 doi (NATIONALLICENCE)springer-10.1007/s10924-011-0334-0 Eco-Synthesis of PVA/Chitosan Hydrogels for Biomedical Application [Elektronische Daten] [A. Abdel-Mohsen, A. Aly, R. Hrdina, A. Montaser, A. Hebeish] A drug delivery system based on physically cross-linked poly vinyl alcohol (PVA)/chitosan blend hydrogels for the release of sparfloxacin antibiotic as a model for drugs was described. Eco-synthesis in current work is based on synthesizing a hydrogel without using chemical crosslinking agents like in the conventional method. In addition all materials are used are non- toxic, safe, non-carcinogenic and can be accepted by the human body without danger. The swelling behavior was tested to be dependent on pH as temperature as well as time and number of freezing thawing cycles. The physical properties of the hydrogels, such as swelling percent, dissolution percent, gel fraction and mechanical properties was assessed. The antimicrobial activity of hydrogels having different compositions was evaluated for both gram positive and gram negative bacteria. Furthermore, the release of antibiotic from hydrogels prepared using the freeze—thawed process was studied. Results obtained disclose that the swelling percent of the hydrogels is pH- dependent and increases by increasing the chitosan percent and decreases with increasing the time and number of freezing cycle. With respect to the antimicrobial activity of the prepared hydrogels, display a positive effect for both gram positive and gram negative bacteria. Freeze-thawed hydrogels could serve as drug delivery system to release sparfloxacin in acidic medium. Indeed, the release percent of sparfloxacin relies on both pH and temperature. Springer Science+Business Media, LLC, 2011 Chitosan nationallicence Drug delivery nationallicence Poly vinyl alcohol nationallicence Hydrogel nationallicence Sparfloxacin nationallicence Abdel-Mohsen A. Institute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice, Studentská 95, 532 10, Pardubice, Czech Republic aut Aly A. National Research Centre-Textile Research Division, El-Buhoth St, 12311, Cairo, Egypt aut Hrdina R. Institute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice, Studentská 95, 532 10, Pardubice, Czech Republic aut Montaser A. National Research Centre-Textile Research Division, El-Buhoth St, 12311, Cairo, Egypt aut Hebeish A. National Research Centre-Textile Research Division, El-Buhoth St, 12311, Cairo, Egypt aut Journal of Polymers and the Environment Springer US; http://www.springer-ny.com 19/4(2011-12-01), 1005-1012 1566-2543 19:4<1005 2011 19 10924 https://doi.org/10.1007/s10924-011-0334-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10924-011-0334-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Abdel-Mohsen A. Institute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice, Studentská 95, 532 10, Pardubice, Czech Republic aut NATIONALLICENCE 700 1- Aly A. National Research Centre-Textile Research Division, El-Buhoth St, 12311, Cairo, Egypt aut NATIONALLICENCE 700 1- Hrdina R. Institute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice, Studentská 95, 532 10, Pardubice, Czech Republic aut NATIONALLICENCE 700 1- Montaser A. National Research Centre-Textile Research Division, El-Buhoth St, 12311, Cairo, Egypt aut NATIONALLICENCE 700 1- Hebeish A. National Research Centre-Textile Research Division, El-Buhoth St, 12311, Cairo, Egypt aut NATIONALLICENCE 773 0- Journal of Polymers and the Environment Springer US; http://www.springer-ny.com 19/4(2011-12-01), 1005-1012 1566-2543 19:4<1005 2011 19 10924 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer