caa a22 4500 445385278 CHVBK 20180317143030.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10924-011-0290-8 doi (NATIONALLICENCE)springer-10.1007/s10924-011-0290-8 Biodegradable Microspheres for Controlled Release of an Antibiotic Ciprofloxacin [Elektronische Daten] [S. Ravindra, K. Varaprasad, N. Narayana Reddy, K. Vimala, K. Mohana Raju] Ciprofloxacin (CF) loaded biodegradable microspheres of Poly(lactide-co-caprolactone)-PF127 (a poloxamer block copolymer of Ethylene Oxide/Propylene Oxide) were prepared by using solvent evaporation technique. The microspheres were characterized by differential scanning calorimetry (DSC) and X-ray diffractometry (X-RD) technique to confirm the polymorphism of ciproflaxacin (CF) drug. The X-RD and DSC techniques indicated molecular level dispersion of CF in the microspheres. Scanning electron micrographic images (SEM) of the microspheres indicated smooth surfaces of the spherical microspheres. Cumulative release characteristics of the matrices for CF, the antibiotic drug, were investigated in pH 7.4 media. It was possible to release CF in controlled manner up to 72h. The developed ciprofloxacin loaded Poly(lactide-co-caprolactone)-PF127 microspheres were evaluated for preliminary antibacterial applications. Springer Science+Business Media, LLC, 2011 Solvent evaporation nationallicence Ciprofloxacin nationallicence Biodegradable microspheres nationallicence Controlled release nationallicence Ravindra S. Synthetic Polymer Laboratory, Department of Polymer Science and Technology, Sri Krishnadevaraya University, 515055, Anantapur, A.P., India aut Varaprasad K. Synthetic Polymer Laboratory, Department of Polymer Science and Technology, Sri Krishnadevaraya University, 515055, Anantapur, A.P., India aut Narayana Reddy N. Synthetic Polymer Laboratory, Department of Polymer Science and Technology, Sri Krishnadevaraya University, 515055, Anantapur, A.P., India aut Vimala K. Synthetic Polymer Laboratory, Department of Polymer Science and Technology, Sri Krishnadevaraya University, 515055, Anantapur, A.P., India aut Mohana Raju K. Synthetic Polymer Laboratory, Department of Polymer Science and Technology, Sri Krishnadevaraya University, 515055, Anantapur, A.P., India aut Journal of Polymers and the Environment Springer US; http://www.springer-ny.com 19/2(2011-06-01), 413-418 1566-2543 19:2<413 2011 19 10924 https://doi.org/10.1007/s10924-011-0290-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10924-011-0290-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ravindra S. Synthetic Polymer Laboratory, Department of Polymer Science and Technology, Sri Krishnadevaraya University, 515055, Anantapur, A.P., India aut NATIONALLICENCE 700 1- Varaprasad K. Synthetic Polymer Laboratory, Department of Polymer Science and Technology, Sri Krishnadevaraya University, 515055, Anantapur, A.P., India aut NATIONALLICENCE 700 1- Narayana Reddy N. Synthetic Polymer Laboratory, Department of Polymer Science and Technology, Sri Krishnadevaraya University, 515055, Anantapur, A.P., India aut NATIONALLICENCE 700 1- Vimala K. Synthetic Polymer Laboratory, Department of Polymer Science and Technology, Sri Krishnadevaraya University, 515055, Anantapur, A.P., India aut NATIONALLICENCE 700 1- Mohana Raju K. Synthetic Polymer Laboratory, Department of Polymer Science and Technology, Sri Krishnadevaraya University, 515055, Anantapur, A.P., India aut NATIONALLICENCE 773 0- Journal of Polymers and the Environment Springer US; http://www.springer-ny.com 19/2(2011-06-01), 413-418 1566-2543 19:2<413 2011 19 10924 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer