caa a22 4500 445385340 CHVBK 20180317143030.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10924-011-0282-8 doi (NATIONALLICENCE)springer-10.1007/s10924-011-0282-8 Poly(vinyl alcohol-co-lactic acid)/Hydroxyapatite Composites: Synthesis and Characterization [Elektronische Daten] [Nita Tudorachi, Aurica Chiriac] There is a wide range of applications where calcium phosphate and hydroxyapatite (HA) are used as biomaterials, e.g. as synthetic bone grafts, coating on metal prostheses (like hip endoprostheses or dental implants) and drug carriers. In the study, the design and synthesis of composites based on poly(vinyl alcohol-co-lactic acid)/hydroxyapatite (PVA-co-LA/HA) with potential for biomedical applications, they are presented. The hydroxyapatite particles were surface-grafted with l(+)-lactic acid in the presence of manganese acetate as catalyst, resulting in modified hydroxyapatite (HAm) with improved capacity of bonding, respectively for the preparation of the composite based on PVA-co-LA/HAm. FT-IR spectra further confirmed the existence of PLA polymer on the surface of HA particles. In synthesis of PVA-co-LA copolymer the different molar ratios PVA/LA (2/1, 1/1, 1/2), toluene/water: 1/2 (as azeotrope solvent mixture) and manganese acetate as catalyst, were used. The composite materials were synthesized in situ with 10wt% HA, and respectively HAm (reported to PVA and lactic acid components). The composite materials were characterized by FTIR spectroscopy, thermal analyses (DSC, DTG), 1H-NMR spectroscopy, particle size distribution and zeta potential. Springer Science+Business Media, LLC, 2011 Biomaterials nationallicence Copolymers nationallicence Poly(vinyl alcohol-co-lactic acid)/hydroxyapatite nationallicence Composites nationallicence Tudorachi Nita "Petru Poni” Institute of Macromolecular Chemistry, 700487, Iasi, Romania aut Chiriac Aurica "Petru Poni” Institute of Macromolecular Chemistry, 700487, Iasi, Romania aut Journal of Polymers and the Environment Springer US; http://www.springer-ny.com 19/2(2011-06-01), 546-558 1566-2543 19:2<546 2011 19 10924 https://doi.org/10.1007/s10924-011-0282-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10924-011-0282-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tudorachi Nita "Petru Poni” Institute of Macromolecular Chemistry, 700487, Iasi, Romania aut NATIONALLICENCE 700 1- Chiriac Aurica "Petru Poni” Institute of Macromolecular Chemistry, 700487, Iasi, Romania aut NATIONALLICENCE 773 0- Journal of Polymers and the Environment Springer US; http://www.springer-ny.com 19/2(2011-06-01), 546-558 1566-2543 19:2<546 2011 19 10924 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer