caa a22 4500 445388293 CHVBK 20180317143038.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s11144-011-0331-2 doi (NATIONALLICENCE)springer-10.1007/s11144-011-0331-2 Optimization of a new isoquinoline derivative preparation [Elektronische Daten] [Andrzej Czyrski, Tadeusz Hermann, Agata Smoląg] Papaverine hydrochloride decomposes in solution easily to papaverinol, papaveraldine and 2,3,9,10-tetramethoxy-12-oxo-12-H-indolo[2,1-a]isoquinolinium chloride 1. The structure of the last compound has been elucidated lately. On the addition of alkali, the brown solution of 1 bleaches. A new compound i.e. 2-(2-carboxy-4,5-dimethoxyphenyl)-6,7-dimethoxyisoquinolinium inner salt 2 is formed. This paper reports the optimization of the compound 2 preparation. Akadémiai Kiadó, Budapest, Hungary, 2011 Kinetics nationallicence Arrhenius equation nationallicence Molar absorption coefficients nationallicence pH50% equilibrium nationallicence Czyrski Andrzej Department of Physical Pharmacy and Pharmacokinetics, K. Marcinkowski University of Medical Sciences, 6 Święcickiego Street, 60-781, Poznań, Poland aut Hermann Tadeusz Department of Physical Pharmacy and Pharmacokinetics, K. Marcinkowski University of Medical Sciences, 6 Święcickiego Street, 60-781, Poznań, Poland aut Smoląg Agata Department of Physical Pharmacy and Pharmacokinetics, K. Marcinkowski University of Medical Sciences, 6 Święcickiego Street, 60-781, Poznań, Poland aut Reaction Kinetics, Mechanisms and Catalysis Springer Netherlands 104/1(2011-10-01), 173-180 1878-5190 104:1<173 2011 104 11144 https://doi.org/10.1007/s11144-011-0331-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11144-011-0331-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Czyrski Andrzej Department of Physical Pharmacy and Pharmacokinetics, K. Marcinkowski University of Medical Sciences, 6 Święcickiego Street, 60-781, Poznań, Poland aut NATIONALLICENCE 700 1- Hermann Tadeusz Department of Physical Pharmacy and Pharmacokinetics, K. Marcinkowski University of Medical Sciences, 6 Święcickiego Street, 60-781, Poznań, Poland aut NATIONALLICENCE 700 1- Smoląg Agata Department of Physical Pharmacy and Pharmacokinetics, K. Marcinkowski University of Medical Sciences, 6 Święcickiego Street, 60-781, Poznań, Poland aut NATIONALLICENCE 773 0- Reaction Kinetics, Mechanisms and Catalysis Springer Netherlands 104/1(2011-10-01), 173-180 1878-5190 104:1<173 2011 104 11144 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer